Određivanje gadolinija metodom ICP-MS nakon sorpcije na nanočesticama željeza

master's thesis

• Title (english): ICP-MS determination of gadolinium after sorption on iron nanoparticles
• Author: Petra Pikec
• Mentor: Sanda Rončević (mentor)
• Committee member: Sanda Rončević (predsjednik povjerenstva)
• Committee member: Ines Primožič (član povjerenstva)
• Committee member: Biserka Prugovečki (član povjerenstva)
• Committee member: Tomislav Jednačak (član povjerenstva)
• Granter: University of Zagreb; Faculty of Science; (Department of Chemistry); Zagreb
• Defense date and country: 2022-10-20, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry

Abstract

Gadolinij (Gd) je glavna komponenta kontrasta za magnetsku rezonanciju (MR). Nakon primjene se
može izlučiti iz organizma nemetaboliziran pri čemu dospijeva u otpadne i prirodne vode te predstavlja
opasnost za okoliš. Nanočestice željeza imaju jedinstvena adsorpcijska i redukcijska svojstva, mobilnost
i nisku cijenu zbog čega imaju široku primjenu u uklanjanju raznih onečišćenja vodenih sustava poput
organskih i kloriranih otapala, pesticida i anorganskih zagađivača. Ispitana je učinkovitost uklanjanja
gadolinija iz vodenih otopina gadolinijevog kontrasta (Gd-DOTA) sorpcijom na nanočesticama željeza
i nanočesticama željeza modificiranim s 2,6-piridindikarboksilnom kiselinom (Fe:PDCA = 2:1).
Metodom spektrometrije masa uz induktivno spregnutu plazmu (ICP-MS) određena je koncentracija
zaostalog gadolinija u otopinama nakon sorpcije. Uspoređena je učinkovitost sorpcije iona Gd3+ na
nanočesticama željeza i nanočesticama modificiranim s PDCA te učinkovitost sorpcije iz standardnih
otopina gadolinija i otopina gadolinijevog kontrasta. Efikasnost uklanjanja gadolinija iz standardnih
otopina doseže do 99,8% s nanočesticama željeza, dok je maksimum uklanjanja iz gadolinijevog
kontrasta 31,3%.

Abstract (english)

Gadolinium (Gd) as main component of MRI contrast agents after application can be excreted from the
human body unmetabolized and therefore present a risk for environment through groundwater pollution.
Iron nanoparticles have unique adsorption and reduction properties, mobility and low cost which is why
they are widely used in removing water pollutants such as organic and chlorinated solvents, pesticides
and inorganic pollutants. Efficiency of removing gadolinium from aqueous gadolinium contrast solution
(Gd-DOTA) by sorption on zero valent iron nanoparticles (nZVI) and nanoparticles modified by
pyridine-2,6-dicarboxylic acid (Fe:PDCA = 2:1) was examined. The concentration of residual
gadolinium after sorption was determined by inductively coupled plasma mass spectrometry (ICP-MS).
The efficiency of sorption of Gd3+ ions on nZVI and those modified with PDCA were compared and the
efficiency of absorption from standard gadolinium solutions and gadolinium contrast solutions were
correlated. Efficiency of gadolinium removal from standard solutions reaches 99,8 % with nZVI, while
removal from gadolinium contrast was 31,3 %.

• Keywords: gadolinij; ICP-MS; nanočestice; željezo; 2; 6-piridindikarboksilna kiselina
• Keywords (english): gadolinium; ICP-MS; iron; nanoparticles; pyridine-2; 6-dicarboxlyic acid
• Language: croatian
• URN:NBN: urn:nbn:hr:217:552545
• Study programme: Title: Graduate university studies in chemistry; specializations in: Research programme; Course: Research programme; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Embargoed access; Embargo expiration date: 2024-10-20
• Created on: 2022-11-04 11:51:24