Patogeneza infekcije virusom ljudske imunodeficijencije

undergraduate thesis

• Title (english): Human immunodeficiency virus pathogenesis
• Author: Petra Šimičić
• Mentor: Silvija Černi (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2015, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Virus ljudske imunodeficijencije (HIV) je virus koji napada imunosni sustav i uzrokuje infekciju te sindrom stečene imunodeficijencije (AIDS). AIDS ubija više ljudi od bilo koje druge infektivne bolesti, a HIV se nastavlja širiti brže od bilo kojeg perzistentnog infektivnog agensa. Stoga nije iznenađujuće što je u proteklom desetljeću bio jedna od najproučavanijih infektivnih čestica. Kada je riječ o razumijevanju patogeneze infekcije virusom HIV, važno pitanje koje se postavlja nije samo kako virus uzrokuje nastanak bolesti, već i zašto; a ti su mehanizmi pojašnjeni detaljnije u ovom radu. Unatoč maloj veličini genoma i nekolicini gena, HIV je iznimno uspješan u iskorištavanju staničnih puteva dok neutralizira i izbjegava različite komponente imunosnog sustava. Najznačajniji napredak ostvaren u tretiranju infekcije virusom HIV jest tretman pacijenata s antiviralnim lijekovima koji mogu suprimirati replikaciju virusa HIV do nedetektabilnih razina te tako odgoditi početak razvoja bolesti. Unatoč nedostatku konačnog lijeka i efikasnog cjepiva, uvidom u patogenezu infekcije virusom HIV dolazimo do važnih spoznaja koje bi mogle omogućiti razvoj terapeutika za uspješnu kontrolu virusa u budućnosti.

Abstract (english)

Human immunodeficiency virus (HIV) is a virus that attacks the immune system and causes HIV infection and acquired immunodeficiency syndrome (AIDS). AIDS kills more people than any other infectious disease, and HIV continues to spread faster than any persistent infectious agent known in the last half century. Therefore, it is not surprising that it became one of the most researched infectious particle in the past decade. The important question when it comes to understanding the pathogenesis of HIV infection is not only how the virus causes disease but also why; and these mechanisms are further explained in this paper. Despite its small genome size and its few genes, HIV is extremely successful in taking advantage of cellular pathways while neutralising and hiding from different components of immune system. The most significant advance in the medical management of HIV infection has been the treatment of patients with antiviral drugs, which can suppress HIV replication to undetectable levels and therefore postpone disease progression. Despite the lack of a cure or an effective vaccine, understanding the pathogenesis of HIV infection has yielded important insights that may enable us to design more effective therapeutics for controlling the virus in the future.

• Keywords: HIV; AIDS; patogeneza infekcije virusom HIV
• Keywords (english): HIV; AIDS; pathogenesis of HIV infection
• Language: croatian
• URN:NBN: urn:nbn:hr:217:952121
• Study programme: Title: Molecular Biology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2017-12-18 13:29:50