Rezistencija na antibiotike u okolišnih izolata bakterije Klebsiella pneumoniae

undergraduate thesis

• Title (english): Antibiotic resistance in environmental isolates of Klebsiella pneumoniae
• Author: Monika Eržen
• Mentor: Jasna Hrenović (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2019, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Bakterija Klebsiella pneumoniae nepokretna je gram-negativna štapićasta bakterija iz porodice Enterobacteriaceae. Smatra se patogenom koji uzrokuje niz ljudskih i životinjskih infekcija. Velika se pozornost pridaje njenoj otpornosti prema antibioticima. Primarno je otporna na ampicilin te karbenicilin, dok u bolnicama lako stječe rezistentnost na velik broj antibiotika koji se primjenjuju u liječenju raznih bolesti. U posljednjih se dvadesetak godina javlja sve veći broj sojeva K. pneumoniae rezistentnih na beta-laktamske antibiotike, a rezistencija je posredovana produkcijom beta-laktamaza proširenog spektra. Bakterija pokazuje stečenu rezistenciju na antibiotike te posjeduje sposobnost stjecanja i prenošenja gena za rezistenciju. Njeni okolišni izolati predstavljaju izvor tih gena koji se mogu prenijeti i na druge bakterijske vrste.

Abstract (english)

Klebsiella pneumoniae is a non-motile Gram-negative bacterium of the family Enterobacteriaceae. It is considered a pathogen which causes a variety of human and animal infections. Much attention is paid to its resistance to antibiotics. It is primarily resistant to ampicillin and carbenicillin, while in hospitals it is easy to acquire resistance to a large number of antibiotics used in the treatment of various diseases. In the last twenty years, an increasing number of strains of K. pneumoniae resistant to beta-lactam antibiotics has been reported, and resistance has been mediated by production of extended-spectrum beta-lactamases. The bacterium shows acquired resistance to antibiotics and possesses the ability to acquire and transmit resistance genes. Its environmental isolates are source of these genes that can be transmitted to other bacterial species.

• Keywords: Klebsiella pneumoniae; rezistentnost
• Language: croatian
• URN:NBN: urn:nbn:hr:217:272871
• Study programme: Title: Environmental Sciences; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) struke znanosti o okolišu (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) struke znanosti o okolišu)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2019-10-11 09:43:07