Signalni put Hedgehog

undergraduate thesis

• Title (english): Hedgehog signaling pathwa
• Author: Anastazija Pahlić
• Mentor: Maja Matulić (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2022-08-24, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Signalni putevi imaju važnu ulogu u primaju i prenošenju informacija unutar stanice i u
međustaničnoj komunikaciji te su bitni za normalno funkcioniranje organizama. Tako je visokokonzervirani signalni put Hedgehog (Hh), koji je prvi put otkriven u vinskoj mušici (lat.
Drosophila melanogaster), važan za prijenos informacija vezanih uz pravilan razvoj organa i
plana tijela tijekom embriogeneze kralježnjaka i beskralježnjaka. Također ima ulogu u
održavanju homeostaze i regeneracije odraslih tkiva. Sastoji se od kaskade signalnih molekula:
proteina Hedgehog koji su ekstracelularni ligandi, receptora Patched, proteina Smothened, Kif7,
Sufu i transkripcijskih faktora Gli. Njihova aktivnost mora biti precizno regulirana kako bi došlo
do pravilne diferencijacije i proliferacije stanica. Poremećaji povezani uz slabu ili onemogućenu
signalizaciju tijekom embrionalnog razvoja povezuju se s urođenim manama, dok povećana
aktivnost signalnog puta u tkivu odraslih jedinki dovodi do nastanka određenih vrsta tumora.
Danas postoje mnoge terapije za liječenje tumora koje se baziraju na inhibiranju signalnog puta
Hh.

Abstract (english)

Signaling pathways play an important role in receiving and transmitting information in the
cell and in the intercellular communication, and are essential for the normal function of the
organism. Thus, the highly conserved Hedgehog (Hh) signaling pathway, which was discovered
in the fruit fly (lat. Drosophila melanogaster), is important for the transmission of information
related to the proper development of organs and body plan during vertebrate and invertebrate
embryogenesis. It also plays a role in maintaining homeostasis and regeneration of adult tissues.
It consists of a cascade of signaling molecules: Hh proteins which are extracellular ligands,
Patched receptor, Smoothened protein, Kif7, Sufu and Gli transcription factors. Their activity
must be precisely regulated in order to allow proper cell differentiation and proliferation to occur.
Abnormalities associated with weak or disabled signaling during embryonic development are
associated with birth defects, while increased activity of the signaling pathway in adult tissues
leads to the formation of certain types of tumors. Today, there are many drugs for the treatment
of tumors which act as Hh signaling pathway inhibitors

• Keywords: signalni put; proteini Hedgehog; embriogeneza; tumori
• Keywords (english): signaling pathway; Hedgehog proteins; embryogenesis; tumors
• Language: croatian
• URN:NBN: urn:nbn:hr:217:701762
• Study programme: Title: Ecology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-09-26 14:34:06