Epigenetski mehanizmi kontrole rasta tumora

undergraduate thesis

• Title (english): Epigenetic tumor growth control mechanisms
• Author: Petra Pavić
• Mentor: Nada Oršolić (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2022-09-02, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Epigenetika je područje znanosti koje proučava nasljedne promjene fenotipa uzrokovane
djelovanjem epigenetskih mehanizama koji ne uključuju promjenu u sekvenci DNA već
promjenu u ekspresiji gena. Uključuju reverzibilne promjene metilacije DNA, modifikacije
histona i aktivnost ne kodirajuće molekule RNA. Pogreške unutar mehanizama mogu
uzrokovati nastanak invazivnog karcinoma. Karcinom karakterizira neprestana proliferacija i
metastaziranje na okolna tkiva. Unatoč dostupnosti brojnih načina liječenja, liječenje
karcinoma je dugotrajno i komplicirano. Zbog reverzibilnosti epigenetskih mehanizama razvija
se epigenetska terapija lijekovima koji uz korištenje poznatih oblika liječenja kao što su
kemoterapija i radioterapija doprinose uspješnom izlječenju. U radu je dat naglasak na
epigenetske promjene u nastanku karcinoma kao i upotreba epigenetske terapije u karcinomu
dojke i kolorektalnog karcinoma.

Abstract (english)

Epigenetics is a field of science that studies heritable changes in phenotype caused by action of
epigenetic mechanisms that do not involve a change in the DNA sequence but a change in gene
expression. They include reversible changes in DNA metylation, histone modifications and
activity od non-coding RNA molecules. Errors within the mechanisms can cause development
of invasive cancer. Cancer is characterized by continuous proliferation and metastasis on
surrounding tissues. Despite the availability of numerous treatment methods, treatment is long
and complicated. Due to the reversibility of epigenetic mechanisms, epigenetic therapy is being
developed which when used in addition to already known forms of treatment like chemotherapy
and radiotherapy, contribute to successful treatment outcome. Breast cancer and colorectal
cancer are described as examples of the influence of epigenetic modifications in the
development of cancer, as well as the use od epigenetic therapy.

• Keywords: epigenetika; metilacija; acetilacija; karcinom; epigenetska terapija
• Keywords (english): epigenetics; methylation; acetylation; cancer; epigenetic therapy
• Language: croatian
• URN:NBN: urn:nbn:hr:217:879218
• Study programme: Title: Ecology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-10-04 12:49:20