Priprava i karakterizacija kompleksa nikla(II) s makrozonskim 4'' derivatom azitromicina izvedenim iz 4-formilbenzojeve kiseline

master's thesis

• Title (english): Synthesis and characterization of nickel(II) coordination compounds with macrozone 4'' azythromicin derivative derived from 4-formylbenzoic acid
• Author: Ema Hošnjak
• Mentor: Predrag Novak (mentor)
• Mentor: Kristina Smokrović (komentor)
• Committee member: Predrag Novak (predsjednik povjerenstva)
• Committee member: Đani Škalamera (član povjerenstva)
• Committee member: Ivica Đilović (član povjerenstva)
• Committee member: Tomislav Jednačak (član povjerenstva)
• Granter: University of Zagreb; Faculty of Science; (Department of Chemistry); Zagreb
• Defense date and country: 2022-09-09, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry

Abstract

Makrozoni su novi konjugati azitromicina i derivata tiosemikarbazona koji pokazuju izvrsno
antibakterijsko djelovanje in vitro na odabrane Gram-pozitivne i Gram-negativne bakterije.
Zbog sve većeg razvoja bakterijske rezistencije na dosadašnje antibiotike cilj mnogih
istraživanja u medicinskoj i farmaceutskoj kemiji je razvoj novih spojeva s poboljšanom
biološkom aktivnošću. Nikal je element u tragovima bitan za bakterije, biljke životinje i ljude
i kao kofaktor ima važnu ulogu u mnogim enzimima. U nizu slučajeva su kompleksi nikla s
tiosemikarbazonima pokazali veću biološku aktivnost od nekompleksiranih liganada. U ovom
je radu uspješno pripravljen kompleks nikla(II) s makrozonskim 4'' derivatom azitromicina,
koji je dobiven konjugacijom 4''-aminopropilnog derivata azitromicina i kompleksa nikla(II) s
tiosemikarbazonom. Pripravljeni spoj okarakteriziran je spektroskopijom NMR. Također je
određena biološka aktivnost spoja in vitro na susceptibilne i rezistentne sojeve bakterija.

Abstract (english)

Macrozones are new conjugates of azithromycin and thiosemicarbazones that possess
excelent in vitro antibacterial activity against selected Gram-positive and Gram-negative
bacteria. Due to the increasing number of macrolide-resistant bacteria, the aim of many
studies in medicinal and pharmaceutical chemistry is development of new compounds with
improved biological activity. Nickel is a trace element essential for bacteria, plants, animals
and humans. In multiple cases, nickel complexes with thiosemicarbazones showed increased
biological activity than uncomplexed ones. In this study succesful synthesis and structural
characterisation of nickel(II) coordination compounds with macrozone 4'' derivative of
azithromycin have been performed using NMR spectroscopy. In vitro biological activity of
the compound against susceptible and resistant bacterial strains was also determined and
discussed.

• Keywords: azitromicin; biološka aktivnost; kompleksi nikla(II); makrolidi; spektroskopija NMR
• Keywords (english): azithromycin; biological activity; macrolides; nickel(II) complexes; spectroscopy NMR
• Language: croatian
• URN:NBN: urn:nbn:hr:217:840933
• Project: Number: IP-2018-01-8098; Title: Makrozoni, novi konjugati makrolidnih antibiotika: Dizajn, priprava i interakcije; Title: Macrozones, New Conjugates of Macrolide Antibiotics: Design, Synthesis and Interactions; Acronym: Makrozoni/Macrozones; Leader: Predrag Novak; Jurisdiction: Croatia; Funder: HRZZ; Funding stream: IP
• Study programme: Title: Graduate university studies in chemistry; specializations in: Research programme; Course: Research programme; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-10-06 09:17:50