Triptaminske soli sa halogeniranim karboksilnim kiselinama ; Novi i stari osnovnoškolski nastavni program kemije.

master's thesis

• Title (english): Tryptaminic salts of halogenated carboxylic acids ; New and old syllabus of primary school chemistry
• Author: Matea Grabovac
• Mentor: Nenad Judaš (mentor)
• Committee member: Nenad Judaš (predsjednik povjerenstva)
• Committee member: Iva Juranović Cindrić (član povjerenstva)
• Committee member: Đani Škalamera (član povjerenstva)
• Committee member: Branimir Bertoša (član povjerenstva)
• Granter: University of Zagreb; Faculty of Science; (Department of Chemistry); Zagreb
• Defense date and country: 2021-09-30, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry

Abstract

Cilj je omogućiti predviđanje konformacije triptaminskih tijela u kristalnim fazama produkata
njihovih reakcija s karboksilnim kiselinama i odrediti njihovu iskoristivost kao potencijalnih
molekula za dizajniranje kristalnih struktura. Dodatno, prepoznati čimbenike koji određuju
torzijske kutove C13–C12–C11–N11 i C110–C13–C12–C11. Ciljani produkti pripremljeni su
miješanjem metanolnih i metanol-benzenskih otopina triptamina i halogeniranih karboksilnih
kiselina (2-klor-5-nitrobenzojeve, 2-klorbenzojeve, 3-klorbenzojeve, 2-brombenzojeve,
4-brombenzojeve, 3-jodbenzojeve, trikloroctene i mezo-dibromjantarne kiseline). Dobiveni
produkti karaterizirani su ATR i 15N NMR spektroskopijom. Kemijski pomak atoma dušika
uspoređivan je u odnosu na dva referentna 15N NMR spektra – spektar čistog triptamina i
spektar triptaminijevog hidroklorida (za kojeg je pretpostavljeno da je potpuno ionski kristal).
Prema dobivenim ATR IR i
15N NMR spektrima, dobivene produkte nije moguće jednoznačno
karakterizirati kao kokristalne produkte ili ionske soli.
U metodičkom dijelu dana je usporedba starog i novog osnovnoškolskog programa kemije te je
predložen 90-minutni nastavni sat koji se temelji na strategiji učenja otkrivanjem, a u kojem
učenici uče o povezanosti građe sustava na atomsko-molekulskoj razini s makroskopskim
svojstvima tvari.

Abstract (english)

The goal was to grow data that will enable prediction of conformation of tryptaminic moieties
in crystal phases of their aducts with carboxylic acids and determine their potential to be used
as tectons in crystal structure design. Additionally, to recognize parameters that influence or
determine torsion angles C13–C12–C11–N11 i C110–C13–C12–C11. Aducts were prepared
by mixing methanol or benzene-methanol solutions of tryptamine and halogenated acids (2-
chloro-5-nitrobenzoic acid, 2-chlorbenzoic acid, 3-chlorobenzoic acid, 2-bromobenzoic acid,
3-bromobenzoic acid, 4-bromobenzoic acid, 3-iodobenzoic acid, 4-iodobenzoic acid,
trichloroacetic acid and mezo-dibromosuccinic acid). Products were characterized by ATR IR
and 15N NMR spectroscopy. Chemical shift of nitrogen atoms were compared with two
references: the chemical shifts of analogous nitrogen atoms in solid pure tryptamine and in solid
of tryptaminium hydrochloride. According to measured ATR IR and 15N NMR spectra it is not
possible to uneqvivocally classify products as cocrystals or salts.
In methodical part a comparison of old and new primary school chemical syllabuses was given
together with a 90-minute classroom founded on inquiry learning strategy during which pupils
will learn how macroscopic properties of a compound are related to its structure on atomicmolecular level.

• Keywords: triptaminijske soli; kristalna struktura; molekulska struktura; organske soli; nastava kemije; učenje otkrivanjem
• Keywords (english): tryptamonium salts; crystal structure; molecular structure; organic salts; teaching chemistry; guided inquiry learning.
• Language: croatian
• URN:NBN: urn:nbn:hr:217:581121
• Study programme: Title: Graduate university studies in chemistry; specializations in: Educational programme; Course: Educational programme; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra edukacije kemije (magistar/magistra edukacije kemije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access; Embargo expiration date: 2023-09-30
• Created on: 2022-10-10 09:26:11