Proteini HOX u razvoju organizma

undergraduate thesis

• Title (english): HOX proteins in development of organism
• Author: Vjeko Hrabar
• Mentor: Maja Matulić (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2022-09-05, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Proteini HOX su skupina transkripcijskih faktora, primarno povezana s ulogom regulatora
formacije anteriorno-posteriorne osi u ranom embrionalnom razvoju. Zbog svoje su se važne
uloge u razvojnim procesima održali visoko konzerviranima među pripadnicima životinja
bilatelarne simetrije. Kao i ostali predstavnici porodice proteina Homeobox, sadrže
homeodomenu, trodimenzionalnu strukturu koja im omogućuje interakciju s regulatornim
sekvencama DNA. Njihovo je djelovanje uvjetovano interakcijom s većim brojem, različitih
skupina kofaktora, koji također pripadaju porodici proteina Homeobox te moduliraju svojstva
proteina HOX, odnosno njihovu specifičnost i afinitet vezanja pojedinih regulacijskih
elemenata. Kako su neispravno formirani uzorci ekspresije gena HOX često uzroci
malformacija i pojava nenormalnosti u embrionalnom razvoju, ispravna se ekspresija gena
HOX osigurava regulacijom putem velikog broja, međusobno povezanih, mehanizama.
Međutim, greške u regulaciji ekspresije gena HOX su neminovne te posljedično i pojava
povezanih patoloških stanja, kao što je primjerice razvoj nekih tipova tumora.

Abstract (english)

HOX proteins are a group of transcription factors, primarily associated with the role of
regulators of anterior-posterior axis formation in early embryonic development. Because of
their important role in developmental processes, they have remained highly conserved among
members of animals with bilateral symmetry. Like other members of the Homeobox protein
family, they contain a homeodomain, a three-dimensional structure that enables them to
interact with regulatory DNA sequences. Their action is determined by the interaction with a
large number of different groups of cofactors, which also belong to the Homeobox protein
family and modulate the properties of HOX proteins, that is, their specificity and binding
affinity of individual regulatory elements. As improperly formed patterns of HOX gene
expression are often the cause of malformations and abnormalities in embryonic development,
the correct expression of HOX genes is ensured by regulation through a large number of
interconnected mechanisms. However, errors in the regulation of HOX gene expression are
inevitable and, consequently, the occurrence of related pathological conditions, such as the
development of some cancer types.

• Keywords: transkripcijski faktori; uzorci ekspresije; Drosophila melanogaster; razvojni procesi; proteinske interakcije
• Keywords (english): trascriptional factors; expression patterns; Drosophila melanogaster; development processes; protein interactions
• Language: croatian
• URN:NBN: urn:nbn:hr:217:614458
• Study programme: Title: Molecular Biology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-10-12 09:14:00