Klinička primjena CAR-T imunoterapije

undergraduate thesis

• Title (english): Clinical application of CAR-T immunotherapy
• Author: Franko Klasić
• Mentor: Nada Oršolić (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2022-09-20, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Pojava malignih oboljenja danas je sve češća. Potreba za novim oblicima terapija nužna je za
liječenje sve većeg broja onkoloških pacijenata. CAR-T imunoterapija danas predstavlja
obećavajući pristup liječenju brojnih bolesti, uključujući razne malignitete poput hematoloških
i solidnih tumora, ali svoju primjenu mogla bi naći i u liječenju autoimunih bolesti u budućnosti.
Specifično prepoznavanje antigena kao najznačajnija karakteristika CAR-T stanica omogućuje
precizno usmjeravanje CAR-T imunoterapije na bolesne stanice i tkiva. Visoka cijena i
zahtjevnost proizvodnje CAR-T stanica ograničava njen pristup velikom broju pacijenata.
Istraživanja koja su usmjerena na otkrivanje novih načina kreiranja CAR-T stanica te
istraživanja usmjerena na otkrivanje specifičnih antigena na koje se mogu usmjeriti CAR-T
stanice doprinijet će u otkrivanju punog potencijala ovog oblika imunoterpaije.

Abstract (english)

The occurrence of malignancies is on the rise. The need for development of new types of
immunotherapy is crucial for treating a rising number of oncological patients. CAR-T
immunotherapy gives a promising approach in threating number of diseases, including a
number of haematological malignancies and solid tumors, but also CAR-T immunotherapy in
future could be used for treating autoimmune disease. Specific recognition of antigens as the
main characteristic of CAR-T cells provides a precise targeting of abnormal cells and tissues.
High price and challenges in creating CAR-T cells make them less available to the number of
patients. Researches that are amid towards finding new ways of creating CAR-T cells and
researches aimed towards finding specific antigens that CAR-T cells can target will make a
contribution to discovering the full potential that can be used from this type of immunotherapy.

• Keywords: imunologija; CAR-T imunoterapija; tumor; liječenje
• Keywords (english): immunology; CAR-T immunotherapy; cancer; treatment
• Language: croatian
• URN:NBN: urn:nbn:hr:217:495604
• Study programme: Title: Ecology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-10-12 09:19:38