Proučavanje sila odgovornih za pozicioniranje kromosoma tokom diobe ljudskih stanica

master's thesis

• Title (english): Study of the forces responsible for the positioning of chromosomes during human cell division
• Author: Ivana Perković
• Mentor: Nenad Pavin (mentor)
• Committee member: Nenad Pavin (predsjednik povjerenstva)
• Committee member: Matko Glunčić (član povjerenstva)
• Committee member: Maja Planinić (član povjerenstva)
• Committee member: Tomislav Bokulić (član povjerenstva)
• Committee member: Katarina Jeličić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Science; (Department of Physics); Zagreb
• Defense date and country: 2022-09-30, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Physics

Abstract

Stanična dioba je esencijalni proces kontinuiteta života. Tokom stanične diobe formira se diobeno vreteno koje je odgovorno za ispravnu podjelu genetskog materijala na novonastale stanice kćeri. Diobeno vreteno kao aktivan element mitoze sadrži mikrotubule, motorne proteine te različite dodatne proteine čija je uloga ključna u samom formiranju diobenog vretena kao i pravilnom pozicioniranju kromosoma koje rezultira uspješnom podjelom genetskog materijala. Spomenuti elementi generiraju sile,... More koje će se koristiti za opisivanje mehanizma poravnanja kromosoma na ekvatorijalnoj ravnini diobenog vretena. U ovom diplomskom radu proučavan je model koji razmatra sile interakcije kinetohornih i premosnih mikrotubula, gdje su premosni mikrotubuli definirani kao mikrotubuli koji se protežu između sestrinskih kinetohora. Dodatne sile koje su proučavane uključuju sile generirane od strane motornih proteina i pasivnih vezivnih proteina na područjima antiparalelnih, odnosno paralelnih preklapanja premosnih i kinetohornih vlakana, interakciju kinetohora s mikrotubulima te ravnotežne sile između sestrinskih kinetohora. Less

Abstract (english)

Cell division is an essential process of life continuity. During cell division, a mitotic spindle is formed, which is responsible for the correct division of genetic material into newly formed daughter cells. The spindle, as an active element of mitosis, contains microtubules, motor proteins and various additional proteins whose role is crucial in the formation of the spindle itself, as well as in the proper positioning of chromosomes, which results in the successful division of genetic... More material. The mentioned elements generate forces, which will be used to describe the mechanism of chromosome alignment on the equatorial plane of the mitotic spindle. In this thesis we use a model that considers the interaction forces of kinetochore and bridging microtubules, where bridging microtubules are defined as microtubules that extend between sister kinetochores. Additional forces that were studied include forces generated by motor proteins and passive crosslinkers at the areas of antiparallel and parallel overlaps of bridging and kinetochore fibers, kinetochore interaction with microtubules, and equilibrium forces between sister kinetochores. Less

• Keywords: pozicioniranje kromosoma; dioba ljudskih stanica
• Language: croatian
• URN:NBN: urn:nbn:hr:217:444136
• Study programme: Title: Physics; specializations in: Education; Course: Education; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra edukacije fizike (magistar/magistra edukacije fizike)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-10-19 10:37:53