Zastupljenost serotipova bakterije Streptococcus pneumoniae među sojevima rezistentnim na makrolide

master's thesis

• Title (english): Distribution of Streptococcus pneumoniae serotypes among macrolide-resistant strains
• Author: Sanja Mohila
• Mentor: Jasmina Vraneš (mentor)
• Committee member: Ana Galov (predsjednik povjerenstva)
• Committee member: Jasna Lajtner (član povjerenstva)
• Committee member: Jasna Hrenović (član povjerenstva)
• Committee member: Jasmina Vraneš (član povjerenstva)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2011-01-31, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Streptococcus pneumoniae često kolonizira ždrijelo djece, a kad je imunost domaćina nedostatna može se rasprostranjivati dalje i izazvati upalu srednjeg uha, pneumoniju ili čak sepsu ili meningitis. Rezistencija na antibiotike S. pneumoniae predstavlja važan javno-zdravstveni izazov u mnogim zemljama. U ovom istraživanju prikupljeno je ukupno 165 izolata S. pneumoniae rezistentnih na makrolide u djece mlađe od 16 godina u različitim regijama Hrvatske (zagrebačko, riječko, osječko i varaždinsko područje). Svrha istraživanja bila je usporedba zastupljenosti pojedinih serotipova među rezistentnim sojevima S. pneumoniae. Najčešći serotipovi su bili 19A i 19F. Drugi serotipovi (1, 3, 5, 8, 6A, 6B, 6C, 9, 10, 11, 14, 15, 17 i 18C) detektirani su s niskom zastupljenošću. Makrolidna rezistencija kod sojeva prikupljenih u Osijeku i Varaždinu bila je udružena sa serotipom 19A, dok je makrolidna rezistencija sojeva prikupljenih u Rijeci i Zagrebu bila udružena sa serotipom 19F (p<0,01). Pokrivenost serotipova sedam-valentnim konjugiranim cjepivom je niska u osječkoj i varaždinskoj regiji te je opaženo pojavljivanje serotipa 19A koji nije uključen u sedam-valentno konjugirano cjepivo među sojevima rezistentnim na makrolide.

Abstract (english)

Streptococcus pneumoniae commonly colonises the nasopharynx of children, and when the host's immunity is impaired it can spread and cause otitis media, sinusitis, pneumonia or even sepsis or meningitis. Antibiotic resistance within Streptococcus pneumoniae represents a major healthcare challenge in many countries. In this study, a total of 165 macrolide-resistant isolates, were obtained from children under 16 years of age in different regions of Croatia (Zagreb, Rijeka, Osijek and Varazdin Regions). The aim of the study was to compare the distribution of the serotypes among resistant strains. The most common serotypes were 19A and 19F. Other serotypes (1, 3, 5, 8, 6A, 6B, 6C, 9, 10, 11, 14, 15, 17 and 18C) were detected with a low frequency.The macrolide-resistance in strains collected in Osijek and Varazdin regions was associated with serotype 19A, and the resistance in strains collected in Rijeka and Zagreb regions was associated with serotype 19F (p<0.01). Serotype coverage for the 7-valent conjugate vaccine in Osijek and Varazdin region is low and emergence of a macrolide-resistant serotype 19A pneumococcal strain not included in the 7-valent conjugate vaccine is detected.

• Keywords: Streptococcus pneumoniae; rezistencija na makrolide; serotip; cjepivo
• Keywords (english): Streptococcus pneumoniae; macrolide resistance; serotype; vaccine
• Language: croatian
• URN:NBN: urn:nbn:hr:217:643528
• Study programme: Title: Experimental Biology; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra eksperimentalne biologije (magistar/magistra eksperimentalne biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Access restricted to students and staff of home institution
• Created on: 2017-05-03 09:37:15