IMMUNOGLOBULIN G GLYCOSYLATION IN COVID-19 DISEASE

doctoral thesis

• Title (croatian): GLIKOZILACIJA IMUNOGLOBULINA G U BOLESTI COVID-19
• Author: Tea Pribić
• Mentor: Irena Trbojević Akmačić (mentor)
• Committee member: Olga Gornik Kljaić (predsjednik povjerenstva)
• Committee member: Dijana Škorić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2023-04-03, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology
• Universal decimal classification (UDC): 577 - Biochemistry. Molecular biology. Biophysics

Abstract

The ongoing pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
has become one of the major health problems in the world. SARS-CoV-2 infection leads to
a disease caused by coronavirus (COVID-19), with a spectrum of symptoms ranging from
asymptomatic to life-threatening pneumonia and death. A variation in the severity of disease
symptomsis one of the central questions in COVID-19 pandemics. Immunoglobulin G (IgG),
the most abundant glycoprotein in human blood plasma, is one of the key molecules in
immune response. Glycosylation of IgG has been poorly studied in COVID-19, but previous
studies on a small sample size have shown that there is an association between glycosylation
of IgG and COVID-19 severity. As a part of this doctoral thesis study, the variability of IgG
N-glycome in COVID-19 will be extensively studied for the first time, in relation to the
disease severity and time period after diagnosis.

Abstract (croatian)

Pandemija koronavirusa 2 (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2)
koji izaziva teški akutni respiratorni sindrom postala je jedan od glavnih zdravstvenih
problema u svijetu. Infekcija SARS-CoV-2 dovodi do bolesti uzrokovane koronavirusom
(COVID-19) sa spektrom simptoma koji se kreću od asimptomatske bolesti do po život
opasne upale pluća i smrti. Uzroci razlika u jačini simptoma kod zaraženih jedno je od
glavnih pitanja u pandemiji COVID-19. Imunoglobulin G (IgG), najzastupljeniji glikoprotein
u ljudskoj krvnoj plazmi, jedna je od ključnih molekula u imunosnom odgovoru. Unatoč
tome, glikozilacija IgG-a je do sada slabo proučavana u bolesnika s COVID-19, a dosadašnje
studije na malom broju uzoraka su pokazale da postoji povezanost glikozilacije IgG-a i težine
bolesti COVID-19. U sklopu ovog doktorskog istraživanja prvi put će biti detaljno
analizirana varijabilnost IgG N-glikoma u COVID-19, ovisno o jačini simptoma te vremenu
trajanja bolesti.

• Keywords: COVID-19; glycans; glycosylation; immunoglobulin G; SARS-CoV-2
• Keywords (english): COVID-19; glikani; glikozilacija; immunoglobulin G; SARS-CoV-2
• Language: english
• URN:NBN: urn:nbn:hr:217:144487
• Promotion: 2023
• Study programme: Title: Biology; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija (doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access; Embargo expiration date: 2024-04-03
• Created on: 2023-05-04 11:02:21