Uloga TLR-a u upali i imunosti na tumor

undergraduate thesis

• Title (english): The Role of TLRs in Inflammation and Tumor Immunity
• Author: Stipe Adžić
• Mentor: Nada Oršolić (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2023-09-06, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Receptori slični Tollu predstavljaju evolucijski konzerviranu skupinu receptora koji čine prvu liniju
zaštite organizma od stranih patogena. Oni prepoznaju komponente patogenih mikroorganizama,
inicirajući tako upalnu reakciju i aktivaciju protuvirusne obrane. Prepoznavanje takvih obrazaca
potiče oslobađanje upalnih medijatora i kemokina koji privlače imunosne stanice na mjesto
infekcije. Nadalje, receptori TLR imaju ključnu ulogu u regulaciji programirane stanične smrti te
održavanju homeostaze organizma. Istraživanja sugeriraju da se umjetnom aktivacijom receptora
TLR može potaknuti imunosni odgovor temeljen na prirodnoubilačkim stanicama i T-limfocitima.
Navedena strategija pokazuje obećavajuće naznake u kontekstu protutumorske terapije. U ovom
radu predstavljena je osnovna uloga receptora TLR u održavanju upalnih procesa i imunosti protiv
tumora. Podrobno je opisana primjena ovih receptora u poticanju željenog protutumorskog učinka
te njihova potencijalna korist u kliničkoj praksi. Ova terapija, bilo samostalno ili u kombinaciji s
drugim imunoterapijskim pristupima, predstavlja obećavajuće područje istraživanja u borbi protiv
raka.

Abstract (english)

Toll-like receptors (TLRs) represent an evolutionarily conserved group of receptors that constitute
the first line of defense against foreign pathogens in the body. These receptors recognize pathogenassociated patterns, thereby initiating an inflammatory reaction and triggering the activation of
antiviral defenses. Recognition of such patterns leads to the release of inflammatory mediators and
chemokines that attract immune cells to the site of infection. Furthermore, Toll-like receptors play
a crucial role in regulating cell death and maintaining organismal homeostasis. Research suggests
that artificial activation of TLR signaling can stimulate an immune response based on T cells and
natural killer cells. The mentioned strategy shows promising indications in the context of antitumor
therapy. This paper presents the fundamental role of TLRs in maintaining inflammatory processes
and immunity against tumors. The application of these receptors in promoting the desired antitumor
effect is described in detail, along with their potential benefits in clinical practice. This therapy,
whether used independently or in combination with other immunotherapeutic approaches,
represents a promising area of research in the fight against cancer.

• Keywords: programirana stanična smrt; tumorski mikrookoliš; agonist; antagonist; imunoterapija
• Keywords (english): programmed cell death; tumor microenvironment; agonist; antagonist; immunotherapy
• Language: croatian
• URN:NBN: urn:nbn:hr:217:734639
• Study programme: Title: Molecular Biology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-09-12 11:10:25