Mehanizmi nastanka multiple skleroze

undergraduate thesis

• Title (english): Mechanisms of multiple sclerosis origin
• Author: Lea Balić
• Mentor: Petra Korać (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2023-09-19, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Multipla skleroza je kronična autoimuna upalna bolest središnjeg živčanog sustava koju
karakterizira prisutnost plakova ili lezija u tkivu središnjeg živčanog sustava. Lezije nastaju zbog
demijelinizacije i degeneracije aksona, procesa koji je posljedica autoimune upalne reakcije.
Bolest se manifestira kroz niz neuroloških simptoma, a razvoj bolesti ovisi o tipu multiple skleroze
od kojeg pacijent boluje. Zašto točno nastaje autoimuni odgovor još nije posve razjašnjeno, no dio
odgovora vjerojatno je povezan s molekulskom mimikrijom između antigena podrijetla od
patogena i komponenti mijelinskog ovoja neurona. Identificirani su mnogi faktori rizika,
uključujući infekciju Epstein-Barrovim virusom, varijante gena HLA, izloženost sunčevoj
svjetlosti i prehrambene navike.

Abstract (english)

Multiple sclerosis is a chronic autoimmune disease of the central nervous system which is
characterized by the presence of plaques or lesions in the tissue of the central nervous system.
Lesions are formed as a result of demyelination and degeneration of axons, a process which is the
consequence of an autoimmune inflammatory reaction. The disease is manifested through a range
of neurological symptoms, and the development of the disease is dependent on the type of multiple
sclerosis which the patient is presenting. Exactly why the autoimmune reaction is initiated is still
unclear, however, a part of the answer may lay in the molecular mimicry between an antigen
originating from a pathogen and the components of the myelin sheath of neurons. Many risk factors
have been identified, including Epstein-Barr virus infection, variants of HLA genes, sunlight
exposure and dietary habits

• Keywords: demijelinizacija; autoimunost; patogeneza; Epstein-Barrov virus; rizični faktori
• Keywords (english): demyelination; autoimmunity; pathogenesis; Epstein-Barr virus; risk factors
• Language: croatian
• URN:NBN: urn:nbn:hr:217:342359
• Study programme: Title: Molecular Biology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-09-20 12:34:52