UČINAK INHIBITORA SGLT2 NA MARKER STRESA MIOCITA (NT-proBNP) U ŠEĆERNOJ BOLESTI TIPA 2

doctoral thesis

• Title (english): THE EFFECT OF SGLT2 INHIBITORS ON MARKER OF MYOCYTE STRESS (NTproBNP) IN TYPE 2 DIABETES
• Author: Petra Grubić Rotkvić
• Mentor: Maja Cigrovski Berković (mentor)
• Committee member: Vesna Benković (predsjednik povjerenstva)
• Committee member: Ines Bilić-Ćurčić (član povjerenstva)
• Committee member: Matias Trbušić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2023-09-20, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology
• Universal decimal classification (UDC): 577 - Biochemistry. Molecular biology. Biophysics

Abstract

U ovoj prospektivnoj opservacijskoj studiji procjenjivani su kardiovaskularni učinci
inhibitora kotransportera natrij-glukoza 2 (SGLT2) kod bolesnika sa šećernom bolesti tipa 2 u
kojih je postojala loša glukoregulacija na monoterapiji metforminom te im je bila potrebna
intenzifikacija terapije (SGLT2 inhibitori ili inhibitori dipeptidil-peptidaze 4). Na početku i
nakon šest mjeseci dodatne terapije obavljena je krvna analiza te fizikalni i ehokardiografski
pregled. Nisu nađene značajne razlike između skupina u biomarkerima miocitnog i
oksidacijskog stresa, upale te krvnom tlaku, dok su se indeks tjelesne mase, trigliceridi,
aspartat-aminotransferaza, mokraćna kiselina, E/E’, deceleracijsko vrijeme i sistolički tlak u
plućnoj arteriji značajno snizili, a udarni volumen i indeksirani udarni volumen te lipoprotein
visoke gustoće, hematokrit i hemoglobin značajno povisili u skupini na SGLT2 inhibitorima.
Iz navedenog proizlazi da mehanizmi djelovanja SGLT2 inhibitora podrazumijevaju brze
promjene u odnosu masnog i nemasnog tkiva, metaboličkim parametrima, zatim smanjeno
srčano opterećenje te poboljšanje dijastoličkih i sistoličkih parametara srčane funkcije.

Abstract (english)

This prospective observational study evaluated the cardiovascular effects of sodium
glucose cotransporter 2 inhibitors (SGLT2i) in patients with type 2 diabetes and poor
glucoregulation on metformin who needed additional therapy (SGLT2i or dipeptidyl peptidase4 inhibitors in the control group). At the beginning and after six months of additional therapy,
laboratory analysis, physical and echocardiographic examination were performed. There were
no significant differences between the two groups in terms of biomarkers of myocyte and
oxidative stress, inflammation and blood pressure. Body mass index, triglycerides, aspartate
aminotransferase, uric acid, E/E’, deceleration time, and systolic pressure in the pulmonary
artery significantly decreased, while stroke volume, and indexed stroke volume as well as highdensity lipoprotein, hematocrit, and hemoglobin, significantly increased in the group on
SGLT2i. According to the results, SGLT2i mechanisms of action obviously comprise rapid
changes in body composition and metabolic parameters, reduced cardiac load, and
improvement in diastolic and systolic heart parameters.

• Keywords: šećerna bolest tipa 2; srčano zatajivanje; SGLT2 inhibitori; NT-proBNP; biomarkeri; ehokardiografija
• Keywords (english): type 2 diabetes; heart failure; SGLT2 inhibitors; NT-proBNP; biomarkers; echocardiography
• Language: croatian
• URN:NBN: urn:nbn:hr:217:371256
• Promotion: 2023
• Study programme: Title: Doctoral study; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti u području prirodnih znanosti (doktor/doktorica znanosti u području prirodnih znanosti)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Embargoed access; Embargo expiration date: 2025-09-20
• Created on: 2023-11-15 12:40:46