Mehanizmi alternativnog prekrajanja u biljaka

undergraduate thesis

• Title (english): Mechanisms of alternative splicing in plants
• Author: Iva Marković
• Mentor: Dunja Leljak-Levanić (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2023-07-12, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Alternativno prekrajanje pre-mRNA je ključan mehanizam regulacije u eukariota koji omogućuje stvaranje više izoformi mRNA iz jednog gena, proširujući raznolikost proteina. Proces alternativnog prekrajanja u biljaka je i dalje većinski neistražen, no procjenjuje se da do 70% gena u biljaka generira više izoformi. Alternativno prekrajanje ima ulogu u regulaciji stabilnosti transkripta, funkcije proteina i njihove lokalizacije, čime utječe na razvoj biljaka i njihov odgovor na stres. Novi alati za analizu transkriptoma omogućuju napretke u istraživanjima alternativnog prekrajanja. U ovom radu dan je pregled osnovnih mehanizama alternativnog prekrajanja, njegovog utjecaja na raznolikost proteina, evolucije, uloge u razvoju biljaka i alata za njegovu identifikaciju.

Abstract (english)

Alternative splicing of pre-mRNA is a crucial regulatory mechanism in eukaryotes that generates multiple mRNA isoforms from a single gene, thus expanding protein diversity. The process of alternative splicing in plants remains largely unexplored, but it is estimated that up to 70% of genes in plants generate multiple isoforms. Alternative splicing plays a role in regulating transcript stability, protein function and localization, thereby influencing plant development and response of plants to stress. Advances in transcriptome analysis tools have enabled progress in studying alternative splicing. This paper provides an overview of the fundamental mechanisms of alternative splicing, its impact on protein diversity, evolution, roles in plant development, and tools for its identification.

• Keywords: procesiranje RNA; spliceosom; razvoj biljaka
• Keywords (english): RNA processing; spliceosome; plant development
• Language: croatian
• URN:NBN: urn:nbn:hr:217:054413
• Study programme: Title: Molecular biology-University undergraduate programme; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-04-02 09:36:08