Mezolimbički put dopamina

undergraduate thesis

• Title (english): Mesolimbic dopamine pathway
• Author: Vedran Bajšanski
• Mentor: Julija Erhardt (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2024-07-04, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Mezolimbički put dopamina jedan je od četiri najvažnija puta dopamina u mozgu. Povezuje
ventralno tegmentalno područje, gdje dopamin prvotno nastaje, i nucleus accumbens u striatumu.
Nakon što je dopamin izlučen, veže se za receptori vezane s G-proteinom. Ovo ne dovodi izravno
do stvaranja akcijskog potencijala otvaranjem ionskih kanala, nego se aktivira signalni put unutar
neurona, čime se mijenja stanična aktivnost, kroz koje može doći do promjene ionskih receptora.
Dopamin se konstantno... More izlučuje iz dopaminergičnih neurona, a izlučivanje se izmjenjuje u
slučaju nagrade, čime se uči o nagrađujućim podražajima. U slučaju nagrade veće od očekivane
luči se više dopamina, a u slučaje manje nagrade inhibira se lučenje dopamina. Nadalje, lučenjem
dopamina u mezolimbičkom putu nastaje želja za nagradom, a sporijim lučenjem nastaje
motivacija. Ovisnost je jedan od najvećih zdravstvenih problema današnjice, a mezolimbički put
dopamina je ključan za nastanak ovisnosti. Sve droge koje mogu izazvati ovisnost utječu na
lučenje dopamina unutar mezolimbičkog puta dopamina zato jer se u njemu određuje kolika želja
za nagradom nastaje. Najvažnija promjena u mezolimbičkim neuronima koja nastaje tijekom
ovisnosti je promjena omjera različitih tipova dopaminskih receptora. Mezolimbički put
dopamina ima kliničku ulogu u nastanku depresije, ADHD-a i shizofrenije. Less

Abstract (english)

Mesolimbic dopamine pathway is one of the four main dopamine pathways. It connects ventral
tegmental area, where dopamine is created, and nucleus accumbens in striatum. After dopamine
secretion, it binds to G protein-coupled receptor. This does not directly lead to the creation of an
action potential by opening ion channels, rather it activates a signaling pathway inside the
neuron, which changes cellular activity, through which a change in ion receptors occurs.
Dopamine is constantly... More secreted from dopaminergic neurons, when reward occurs, the release
changes, thus learning about rewarding stimuli. In the case of a higher-than-expected reward,
more dopamine is secreted, and when the reward is smaller, dopamine secretion is inhibited.
Furthermore, dopamine secretion in the mesolimbic pathway generates wanting for reward, and
slower secretion generates motivation. Addiction is one of the biggest health problems nowadays,
and mesolimbic dopamine pathway is essential for its emergence. Each drug that causes addiction
affects secretion of dopamine within the mesolimbic dopamine pathway because it determines
how much wanting for reward is generated. During addiction, the most important change within
mesolimbic neurons is the change in the dopamine receptors ratio. Mesolimbic dopamine plays a
role in the creation of depression, ADHD and, schizophenia. Less

• Keywords: ovisnost; nagrada; motivacija; učenje; dopaminski receptori; shizofrenija.
• Keywords (english): addiction; reward; motivation; learning; dopamine receptors; schizophrenia
• Language: croatian
• URN:NBN: urn:nbn:hr:217:095292
• Study programme: Title: Ecology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-07-09 15:10:06