prikaz prve stranice dokumenta Light Stimulation of Neurons on Organic Photocapacitors Induces Action Potentials with Millisecond Precision
  Download
PDF 2.37 MB
Scientific paper - Original scientific paper
Light Stimulation of Neurons on Organic Photocapacitors Induces Action Potentials with Millisecond Precision
Advanced Materials Technologies, 7 (2022), 9; 2101159. https://doi.org/10.1002/admt.202101159
Schmidt, Tony; Jakešová, Marie; Đerek, Vedran; Kornmueller, Karin; Tiapko, Oleksandra; Bischof, Helmut; Burgstaller, Sandra; Waldherr, Linda; Nowakowska, Marta; Baumgartner, Christian; Üçal, Muammer; Leitinger, Gerd; Scheruebel, Susanne; Patz, Silke; Malli, Roland; Głowacki, Eric Daniel; Rienmüller, Theresa; Schindl, Rainer More authors...

Cite this document

Schmidt, T., Jakešová, M., Đerek, V., Kornmueller, K., Tiapko, O., Bischof, H. ... Schindl, R. (2022). Light Stimulation of Neurons on Organic Photocapacitors Induces Action Potentials with Millisecond Precision. Advanced Materials Technologies, 7. (9). doi: 10.1002/admt.202101159

Schmidt, Tony, et al. "Light Stimulation of Neurons on Organic Photocapacitors Induces Action Potentials with Millisecond Precision." Advanced Materials Technologies, vol. 7, no. 9, 2022. https://doi.org/10.1002/admt.202101159

Schmidt, Tony, Marie Jakešová, Vedran Đerek, Karin Kornmueller, Oleksandra Tiapko, Helmut Bischof, Sandra Burgstaller, et al. "Light Stimulation of Neurons on Organic Photocapacitors Induces Action Potentials with Millisecond Precision." Advanced Materials Technologies 7, no. 9 (2022). https://doi.org/10.1002/admt.202101159

Schmidt, T., et al. (2022) 'Light Stimulation of Neurons on Organic Photocapacitors Induces Action Potentials with Millisecond Precision', Advanced Materials Technologies, 7(9). doi: 10.1002/admt.202101159

Schmidt T, Jakešová M, Đerek V, Kornmueller K, Tiapko O, Bischof H, and sur.. Light Stimulation of Neurons on Organic Photocapacitors Induces Action Potentials with Millisecond Precision. Advanced Materials Technologies [Internet]. 2022 March 18 [cited 2024 October 10];7(9). doi: 10.1002/admt.202101159

T. Schmidt, et al., "Light Stimulation of Neurons on Organic Photocapacitors Induces Action Potentials with Millisecond Precision", Advanced Materials Technologies, vol. 7, no. 9, March 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:217:840752. [Accessed: 10 October 2024]

Please login to the repository to save this object to your list.
Metadata
Title (english)Light Stimulation of Neurons on Organic Photocapacitors Induces Action Potentials with Millisecond Precision
AuthorTony Schmidt
AuthorMarie Jakešová
AuthorVedran Đerek
AuthorKarin Kornmueller
AuthorOleksandra Tiapko
AuthorHelmut Bischof
AuthorSandra Burgstaller
AuthorLinda Waldherr
AuthorMarta Nowakowska
AuthorChristian Baumgartner
AuthorMuammer Üçal
AuthorGerd Leitinger
AuthorSusanne Scheruebel
AuthorSilke Patz
AuthorRoland Malli
AuthorEric Daniel Głowacki
AuthorTheresa Rienmüller
AuthorRainer Schindl
Author's institutionUniversity of Zagreb
Faculty of Science
(Department of Physics)
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Physics
Abstract (english)
Nongenetic optical control of neurons is a powerful technique to study and manipulate the function of the nervous system. This research has benchmarked the performance of organic electrolytic photocapacitor (OEPC) optoelectronic stimulators at the level of single mammalian cells: human embryonic kidney (HEK) cells with heterologously expressed voltage-gated K+ channels and hippocampal primary neurons. OEPCs act as extracellular stimulation electrodes driven by deep red light. The electrophysiological recordings show that millisecond light stimulation of OEPC shifts conductance-voltage plots of voltage-gated K+ channels by ≈30 mV. Models are described both for understanding the experimental findings at the level of K+ channel kinetics in HEK cells, as well as elucidating interpretation of membrane electrophysiology obtained during stimulation with an electrically floating extracellular photoelectrode. A time-dependent increase in voltage-gated channel conductivity in response to OEPC stimulation is demonstrated. These findings are then carried on to cultured primary hippocampal neurons. It is found that millisecond time-scale optical stimuli trigger repetitive action potentials in these neurons. The findings demonstrate that OEPC devices enable the manipulation of neuronal signaling activities with millisecond precision. OEPCs can therefore be integrated into novel in vitro electrophysiology protocols, and the findings can inspire in vivo applications.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleAdvanced Materials Technologies
Numberingvol. 7, no. 9, 2101159
p-ISSN2365-709X
e-ISSN2365-709X
DOIhttps://doi.org/10.1002/admt.202101159
URN:NBNurn:nbn:hr:217:840752
Publication2022-03-18
ProjectNumber: UIP-2019-04-1753
Title (croatian): Mikro i nano-strukture za 3D opto-bioelektroniku
Title (english): Micro- and nano-structures for 3D opto-bioelectronics
Acronym: 3Doptobio
Leader: Vedran Đerek
Jurisdiction: Croatia
Funding stream: Installation Research Projects
ProjectNumber: KK.01.1.1.02.0013
Title (croatian): Centar za Napredna Istraživanja Kompleksnih Sustava
Title (english): Centre for Advanced Research of Complex Systems
Acronym: CeNIKS
Leader: Mihael Srđan Grbić
Jurisdiction: eu
Funding stream: European Regional Development Fund
ProjectNumber: KK.01.1.1.01.0004
Title (croatian): Provedba vrhunskih istraživanja u sklopu Znanstvenog centra izvrsnosti za kvantne i kompleksne sustave te reprezentacije Liejevih algebri
Title (english): Implementation of top research within the Scientific Center of Excellence for Quantum and Complex Systems, and Representations of Lie Algebras
Acronym: QuantiXLie
Leader: Hrvoje Buljan
Jurisdiction: eu
Funding stream: European Regional Development Fund
Document URLhttps://onlinelibrary.wiley.com/doi/10.1002/admt.202101159
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Public note© 2022 The Authors. Advanced Materials Technologies published byWiley-VCH GmbH. This is an open access article under the terms of theCreative Commons Attribution License, which permits use, distribution andreproduction in any medium, provided the original work is properly cited. First published: 18 March 2022.
Created on2024-08-09 18:26:26