IMPACT OF TRAINING FREQUENCY ON BIOLOGICAL AGE GLYCAN BIOMARKERS AND INJURY PREDISPOSITION

doctoral thesis

• Title (croatian): UTJECAJ UČESTALOSTI TRENIRANJA NA GLIKANSKE BIOMARKERE BIOLOŠKE DOBI I PREDISPOZICIJE ZA NASTANAK OZLJEDA
• Author: Nina Šimunić Briški
• Mentor: Gordan Lauc (mentor)
• Committee member: Aleksandar Vojta (predsjednik povjerenstva)
• Committee member: Dubravko Pavoković (član povjerenstva)
• Committee member: Olga Gornik Kljaić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2024-06-24, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology
• Universal decimal classification (UDC): 577 - Biochemistry. Molecular biology. Biophysics

Abstract

Regular moderate exercise has multiple beneficial effects, yet very little is known about the impact of exercise on immunoglobulin G (IgG) glycosylation. In this thesis, the aim was to analyze the impact of various training frequencies on glycan biomarkers of biological age and to investigate currently related gene variants associated with soft-tissue injuries. The results demonstrated that glycan profiles of regularly moderately active population had the lowest GlycanAge index, 7.5 years less when compared to competing athletes, and 7.4 years less when compared to the inactive population. Furthermore, results supported the association of the COL12A1, COL27A1, Tenascin C and matrix-metalloproteinase 3 (MMP3) gene variants with either increased or reduced risk of developing anterior cruciate ligament ruptures or Achilles tendinopathies, types of injuries that are common in sport, impacting both professional competing athletes and recreational exercisers.

Abstract (croatian)

Redovna umjerena tjelesna aktivnost blagotvorno utječe na cjelokupno zdravlje. Trenutno se još uvijek zna jako malo o utjecaju vježbanja na glikozilaciju imunoglobulina G (IgG). U ovom doktorskom radu cilj je bio istražiti utjecaj učestalosti treniranja na glikanske biomarkere biološke dobi, kao i povezanost trenutno poznatih varijanti gena s ozljedama mekog vezivnog tkiva kod sportaša. Značajno niži GlycanAge indeks potvrđen je u grupi redovnih umjerenih vježbača, dok su profesionalni sportaši i neaktivna popoulacija imali značajno viši GlycanAge indeks. Osim toga, postoji značajna povezanost genskih varijanti unutar COL12A1, COL27A1, Tenascin C (TNC) i matriks-metaloproteinaza 3 (MMP3) gena s povišenim ili smanjenim rizikom od nastanka rupture prednjeg križnog ligamenta i tendinopatija u Ahilovoj tetivi, kod profesionalnih sportaša u odnosu na kontrolnu skupinu. Ozljede ligamenata i tetiva su česte sportske ozljede koje pogađaju i rekreativne i profesionalne sportaše.

• Keywords: Biological Age; Glycosylation; Immunoglobulin G; Single Nucleotide Polymorphism; Sport Injury
• Keywords (croatian): biološka dob; glikozilacija; immunoglobulin G; polimorfizam jednog nukleotida; sportska ozljeda
• Language: english
• URN:NBN: urn:nbn:hr:217:649248
• Promotion: 2024
• Project: Number: IR_2015_28; Title: Istraživanje genskih predispozicija i razvoj testa za prevenciju sportskih ozljeda - GENPrevent; Title: Research on genetic predispositions and development of a test for the prevention of sports injuries; Acronym: GENPrevent; Leader: Gordan Lauc; Jurisdiction: Croatia; Funder: Hrvatska agencija za malo gospodarstvo, inovacije i investicije
• Study programme: Title: Doctoral study; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti u području prirodnih znanosti (doktor/doktorica znanosti u području prirodnih znanosti)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-09-03 11:30:58