Uloga retinoične kiseline u diferencijaciji matičnih stanica sisavaca

undergraduate thesis

• Title (english): The role of retinoic acid in mammalian stem cell differentiation
• Author: Dora Fašnik
• Mentor: Romana Gračan (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2024-07-12, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

U ovom su radu prikazana dosadašnja istraživanja i saznanja o učincima retinoične kiseline koji potiču diferencijaciju matičnih stanica kod sisavaca. Retinoična kiselina je morfogen koji ima širok raspon funkcija tijekom embrionalnog razvoja organizma. Na diferencijaciju matičnih stanica može djelovati na razini genoma ili preko izvangenomskih mehanizama. Također ima velik potencijal u primjeni u terapijske svrhe protiv teških i malignih bolesti. No poznat je i njen oprečni utjecaj na stimulaciju proliferacije stanica. Cilj ovog rada bio je obuhvatiti nove zaključke u ovom širokom području i otvoriti pitanja za buduća istraživanja ključna za bolje razumijevanje mehanizama retinoične kiseline i njene suradnje s drugim molekulama u staničnom mikrookolišu koje oblikuju staničnu sudbinu.

Abstract (english)

This paper presents the current research and findings on the effects of retinoic acid that promote the differentiation of stem cells in mammals. Retinoic acid is a morphogen with a wide range of functions during the embryonic development of an organism. It can influence stem cell differentiation at the genomic level or through non-genomic mechanisms. Additionally, it holds significant potential for therapeutic applications against severe and malignant diseases. However, its contradictory impact on the stimulation of cell proliferation is also well-known. The aim of this paper was to encompass new conclusions in this broad field and to raise questions for future research crucial for a better understanding of the mechanisms of retinoic acid and its interactions with other molecules in the cellular microenvironment that shape cell fate.

• Keywords: retinoične kiseline; mikroRNA; fosforilacija; retinoilacija; terapija protiv raka
• Keywords (english): retinoic acid receptors; mikroRNA; fosforilation; retinoilation; cancer therapy
• Language: croatian
• URN:NBN: urn:nbn:hr:217:242514
• Study programme: Title: Molecular biology-University undergraduate programme; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-09-03 12:47:44