Karakteristike fagoplazmida

undergraduate thesis

• Title (english): Characteristics of phage-plasmids
• Author: Petra Vrsaljko
• Mentor: Ivana Ivančić Baće (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2024-09-10, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Fagoplazmidi su hibridni mobilni genetički elementi koji se mogu prenositi vertikalno unutar
bakterijskih linija u obliku kružnih molekula DNA ili horizontalno upakirani u virusne čestice
između različitih prokariotskih stanica. Ovi elementi imaju velike genome koji sadrže mnoge gene
homologne plazmidima i bakteriofagima što povećava njihovu učinkovitost prijenosa gena.
Fagoplazmidi su brojni i široko rasprostranjeni u raznim bakterijskim vrstama među kojima su
mnoge patogene bakterije od velikog kliničkog značaja. Dokazano je da ovi elementi sudjeluju u
prenošenju raznih adaptivnih gena unutar bakterijskih populacija, uključujući gene koji kodiraju
za antibiotsku rezistenciju. Zbog ovoga fagoplazmidi su predmet intenzivnog istraživanja kako bi
se razumjela njihova evolucija i razvile strategije za suzbijanje širenja sojeva bakterija koji
posjeduju rezistencije na antibiotike.

Abstract (english)

Phage-plasmids are hybrid mobile genetic elements which can be transferred vertically within
bacterial lineages in the form of circular DNA molecules or horizontally packaged in viral particles
between different prokaryotic cells. These elements have large genomes containing many genes
homologous to plasmids and bacteriophages, which increases their gene transfer efficiency. Phageplasmids are numerous and widely distributed in various bacterial species, among which are many
pathogenic bacteria of great clinical importance. It has been proven that these elements participate
in the transmission of various adaptive genes within bacterial populations, including genes that
code for antibiotic resistance. Because of this, phage-plasmids are subject of intensive research in
order to understand their evolution and develop strategies to suppress the spread of antibioticresistant bacterial strains.

• Keywords: hibridni genetički elementi; plazmidi; bakteriofagi; izmjena gena; antibiotska rezistencija; evolucija bakterija
• Keywords (english): hybrid genetic elements; plasmids; bacteriophages; gene exchange; antibiotic resistance; evolution of bacteria
• Language: croatian
• URN:NBN: urn:nbn:hr:217:047595
• Study programme: Title: Molecular biology-University undergraduate programme; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-09-16 16:14:35