Mehanizmi bakterija kojim se stanice domaćina mogu prevesti u tumorske

undergraduate thesis

• Title (english): Bacterial mechanisms that can turn host cells into tumor cells
• Author: Lucija Orlić
• Mentor: Ivana Ivančić Baće (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2017-09-07, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Sve je veći broj istraživanja koja dovode u vezu određene bakterijske vrste i rizik od nastanka raka. Prilikom infekcije, da bi preživjele i razmnožile se, patogene bakterije potiču niz promjena u domaćinskim stanicama. Pritom često dolazi do oštećenja molekule DNA. Različiti faktori virulencije onemogućuju cjelovit odgovor stanice na oštećenje DNA; većina bakterija, poput H. pylori, smanjuje razinu tumor supresora p53, a Listeria monocytogenes uzrokuje degradaciju proteina Mre11. Bakterije... More također mogu utjecati na signalne puteve stanice. H. pylori, Salmonella enterica i Fusobacterium nucleatum aktiviraju signalni put Wnt/β-katenin koji može dovesti do aktivacije gena uključenih u onkogenezu. Signalni putevi MAPK i Akt kontroliraju proliferaciju i apoptozu, a na njihovu regulaciju utječu S. enterica, H. pylori i C. trachomatis. Ovi mehanizmi doprinose razvoju raka jer mogu dovesti stanice domaćina korak bliže transformaciji. Veći je rizik kod kroničnih infekcija jer je organizam izložen takvom utjecaju kroz duži vremenski period. Less

Abstract (english)

A growing number of research is finding a connection between certain species of bacteria and the risk of cancer development. During infection, to survive and proliferate, pathogenic bacteria induce a series of changes in host cells. Simultaneously, DNA damage often occurs. Various virulence factors can disrupt DNA damage response; most bacteria, such as H. pylori, downregulate tumor suppressor p53, while Listeria monocytogenes causes Mre11 degradation. Bacteria can also affect cell... More signaling. H. pylori, Salmonella enterica and Fusobacterium nucleatum activate Wnt/β-catenin signal pathway which can lead to activation of genes involved in oncogenesis. MAPK and Akt signal pathways control cell proliferation and apoptosis, and they are regulated by S. enterica, H. pylori and C. trachomatis. These mechanisms contribute to cancer development because they can bring host cells one step closer to transformation. Chronic infections bring greater risk because the organism is exposed to such influence over a longer period of time. Less

• Keywords: bakterije; tumor
• Keywords (english): bacteria; cancer
• Language: croatian
• URN:NBN: urn:nbn:hr:217:907360
• Study programme: Title: Molecular Biology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2017-09-19 07:11:48