The role of human cytomegalovirus in tumorygenesis

undergraduate thesis

• Title: Uloga ljudskog citomegalovirusa u tumorigenezi
• Author: Ana Vukić
• Mentor: Petra Korać (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2017-09-15, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Ljudski citomegalovirus je herpes virus koji uzrokuje latentne infekcije s mogućnošću reaktivacije. Prisutnost njegovih proteina i nukleinskih kiselina je zabilježena u tkivima brojnih malignih tumora poput glioblastoma, meduloblastoma, neuroblastoma, rabdomiosarkoma, karcinoma dojke, kolorektalnog karcinoma, itd. Ne smatra ga se onkogenim virusom, nego virusom koji sudjeluje u procesu “onkomodulacije”. Preko svojih proteina i nekodirajućih RNA utječe na proliferaciju, preživljavanje, invaziju, imunogeničnost tumorskih stanica i stvaranje faktora angiogeneze. Usprkos brojnim istraživanjima, sam proces onkomodulacije još uvijek nije u potpunosti definiran. Potrebno je još raditi na standardizaciji metoda detektiranja infekcije virusom, ali je bitan cilj i razviti terapeutike koji će spriječiti replikaciju virusa ili djelovati na njegove regulacijske proteine i nekodirajuće RNA.

Abstract (english)

Human cytomegalovirus is a herpes virus that causes latent infections with a possibility of reactivation. Viral proteins and HHV5 nucleic acids have been found in tissues of numerous malignant tumors such as glyoblastomas, medulloblastomas, neuroblastomas, rhabdomyosarcomas, breast carcinoma, colorectal carcinoma, etc. HHV5 is not regarded as oncogenic virus, but rather as a virus that takes part in process known as “oncomodulation”. Activity of its proteins and noncoding RNAs influence proliferation, survival, invasion and immunogenicity of tumor cells and production of angiogenic factors. Despite the fact that many researches have been done on this topic, the process of oncomodulation is not fully understood. It is necessary to standardize sensitive techniques to detect infection, but one of the central aims remains to be development of therapeutic strategies that will prevent HHV5 replication or target its regulatory proteins and noncoding RNAs.

• Keywords: citomegalovirus; onkomodulacija
• Keywords (english): cytomegalovirus; oncomodulation
• Language: croatian
• URN:NBN: urn:nbn:hr:217:744056
• Study programme: Title: Molekularna biologija; Study programme type: sveučilišni; Study level: preddiplomski; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2017-09-19 08:16:02