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undergraduate thesis
7
1
The role of human cytomegalovirus in tumorygenesis
Ana Vukić (2017)
University of Zagreb
Faculty of Science
Department of Biology
Cite this item:
https://urn.nsk.hr/urn:nbn:hr:217:744056
Metadata
Title
Uloga ljudskog citomegalovirusa u tumorigenezi
Author
Ana Vukić
Mentor(s)
Petra Korać
(thesis advisor)
Abstract
Ljudski citomegalovirus je herpes virus koji uzrokuje latentne infekcije s mogućnošću reaktivacije. Prisutnost njegovih proteina i nukleinskih kiselina je zabilježena u tkivima brojnih malignih tumora poput glioblastoma, meduloblastoma, neuroblastoma, rabdomiosarkoma, karcinoma dojke, kolorektalnog karcinoma, itd. Ne smatra ga se onkogenim virusom, nego virusom koji sudjeluje u procesu “onkomodulacije”. Preko svojih proteina i nekodirajućih RNA utječe na proliferaciju, preživljavanje, invaziju, imunogeničnost tumorskih stanica i stvaranje faktora angiogeneze. Usprkos brojnim istraživanjima, sam proces onkomodulacije još uvijek nije u potpunosti definiran. Potrebno je još raditi na standardizaciji metoda detektiranja infekcije virusom, ali je bitan cilj i razviti terapeutike koji će spriječiti replikaciju virusa ili djelovati na njegove regulacijske proteine i nekodirajuće RNA.
Keywords
cytomegalovirus
oncomodulation
Parallel title (English)
The role of human cytomegalovirus in tumorygenesis
Granter
University of Zagreb
Faculty of Science
Lower level organizational units
Department of Biology
Place
Zagreb
State
Croatia
Scientific field, discipline, subdiscipline
NATURAL SCIENCES
Biology
Study programme type
university
Study level
undergraduate
Study programme
Molecular Biology
Academic title abbreviation
univ. bacc. biol. mol.
Genre
undergraduate thesis
Language
Croatian
Defense date
2017-09-15
Parallel abstract (English)
Human cytomegalovirus is a herpes virus that causes latent infections with a possibility of reactivation. Viral proteins and HHV5 nucleic acids have been found in tissues of numerous malignant tumors such as glyoblastomas, medulloblastomas, neuroblastomas, rhabdomyosarcomas, breast carcinoma, colorectal carcinoma, etc. HHV5 is not regarded as oncogenic virus, but rather as a virus that takes part in process known as “oncomodulation”. Activity of its proteins and noncoding RNAs influence proliferation, survival, invasion and immunogenicity of tumor cells and production of angiogenic factors. Despite the fact that many researches have been done on this topic, the process of oncomodulation is not fully understood. It is necessary to standardize sensitive techniques to detect infection, but one of the central aims remains to be development of therapeutic strategies that will prevent HHV5 replication or target its regulatory proteins and noncoding RNAs.
Parallel keywords (Croatian)
citomegalovirus
onkomodulacija
Resource type
text
Access condition
Open access
Terms of use
URN:NBN
https://urn.nsk.hr/urn:nbn:hr:217:744056
Committer
Palma Dizdarević