Mehanizmi protutumorskog djelovanja flavonoida

undergraduate thesis

• Title (english): The antitumor activities of flavonoids
• Author: Irena Migić
• Mentor: Gordana Rusak (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2014, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Flavonoidi su polifenolni spojevi koji se nalaze u voću, povrću, čaju i vinu. Budući da se brojnim istraživanjima pokazalo da flavonoidi posjeduju antibakterijska, protuupalna, antialergijska, antimutagena, antiviralna i protutumorska svojstva oni predstavljaju važan dio ljudske prehrane u borbi protiv raznih bolesti. U ovom radu su opisana neka od tih svojstava, a naglasak je stavljen na protutumorske učinke flavonoida i njihove mehanizme djelovanja. Rak je drugi najčešći ubojica u svijetu, odmah nakon kardiovaskularnih bolesti i predstavlja veliki zdravstveni problem i u razvijenim zemljama i u zemljama u razvoju. Voće i povrće kao glavni izvor flavonoida u ljudskoj prehrani pomažu u prevenciji raka. Ovdje treba naglasiti da flavonoidi iz prehrane za razliku od ostalih terapeutskih tvari pokazuju minimalne nuspojave, lako se apsorbiraju i nisu agresivni za ljusko tijelo poput kemoterapije. Flavonoidi mogu utjecati na brojne biološke procese u razvoju raka poput apoptoze, stanične proliferacije i stanične diferencijacije. Iz tih razloga u posljednja 2-3 desetljeća flavonoidi zaokupljaju sve veći interes znanstvenika u borbi protiv raka. Međutim potrebna su još brojna istraživanja, posebno in vivo istraživanja, kako bi se utvrdili mehanizmi i međudjelovanje brojnih učinaka flavonoida u sprječavanju nastanka i borbi protiv raka i drugih bolesti.

Abstract (english)

Flavonoids are polyphenolic compounds that are found in fruits, vegetables, tea and wine. Because numerous studies have shown that flavonoids possess antibacterial, antiinflammatory, antiallergic, antimutagenic, antiviral and anti-cancer properties they represent an important part of the human diet in the fight against various diseases. This paper describes some of these properties, with the accent on the antitumor effects of flavonoids and their mechanisms of action. Cancer is the second leading killer in the world after cardiovascular disease and is a major health problem in both developed countries and developing countries. Fruits and vegetables as the main source of flavonoids in the human diet help prevent cancer. It should be noted that flavonoids as natural compounds, unlike other therapeutic agents show minimal side effects, they are easily absorbed and they are not aggressive to the human body like chemotherapy. Flavonoids can modulate many biological processes in the development of cancer, such as apoptosis, cell proliferation and cell differentiation. For these reasons during the past 2–3 decades flavonoids occupy more and more attention of scientists in the fight against cancer. However more studies are needed, especially in vivo studies to determine the mechanisms and interaction of the many effects of flavonoids to prevent the development and to fight against cancer and other diseases.

• Keywords: flavonoidi; protutumorski učinak flavonoida
• Keywords (english): flavonoids; antitumor effects of flavonoids
• Language: croatian
• URN:NBN: urn:nbn:hr:217:795401
• Study programme: Title: Ecology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2017-12-08 13:01:06