Patobiologija T-limfoma

undergraduate thesis

• Title (english): Pathobiology of T-lymphoma
• Author: Lucija Ačkar
• Mentor: Petra Korać (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2015, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

T–limfomi su tumori nastali od vlastitih izmijenjenih T–limfocita. Tipovi T–limfoma se međusobno teško razlikuju ukoliko se ne klasificiraju pomoću više, npr. razlike u morfološkoj strukturi zahvaćenog tkiva, imunofenotipu i histokemijske razlike. Poremećen regulatorni mehanizam rekombinacije VDJ gena je najvjerojatnije jedan od prvih i glavnih uzročnika razvoja T–limfoma, osim u malom broju slučajeva kada nastane funkcionalni triplet koji donosi veću varijabilanost TCR-a. U većini slučajeva nastane nefunkcionalni triplet ili stop kodon. T–limfome najčešće karakteriziraju translokacije, no mogu nastati i zbog delecije, ili mutacije u genomu čija je posljedica promijenjena ekspresija panT antigena. Takve stanice su nefunkcionalne i ukoliko ne nastupi programirana stanična smrt nastaju T–limfomi. Smatra se da virusi, npr. EBV, HIV i HTLV1, imaju značajan utjecaj na nastanak T–limfoma. Uočena je povezanost u učestalosti T–limfoma i geografskog položaja gdje je pojedini tip virusa zastupljeniji. Uzevši u obzir crnu, bijelu i žutu rasu, tipovi T–limfoma su različito zastupljeni, što se povezuje sa genetskim sličnostima unutar rase, odnosno razlikama između rasa.

Abstract (english)

T–cell lymphoma is a type of cancer developed from it's own altered T-lymphocytes. Types of T–cell lymphoma are difficult to differentiate unless they are classified using multiple properties, e.g. differences in morphological structure of the affected tissue, immunophenotype and histochemical differences. Disrupted regulatory mechanism of VDJ genes recombination is probably one of the first and major causes of the T–cell lymphoma development. In rare cases the cause is the occurrence of a functional triplet, which brings in higher variability of the TCR, instead of a non-functional triplet or a stop codon. T–cell lymphoma is most often characterised by translocations, but it can be also developed by deletion or genome mutation resulting in changed expression of the panT antigen. These kind of cells are non-functional and if a programmed cellular death does not happen, the T–cell lymphomas develop. It is considered that viruses, e.g. EBV, HTLV1 and HIV have significant influence on the T–cell lymphoma formation. A correlation between the frequency of T–cell lymphoma appearance and geographic location is also perceived. Considering black, white and Asian races, T–cell lymphoma types have different occurrence that is linked to genetic similarities within a particular race as well as to differences between those races.

• Keywords: T–limfomi
• Keywords (english): T–cell lymphoma
• Language: croatian
• URN:NBN: urn:nbn:hr:217:362325
• Study programme: Title: Molecular Biology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2017-12-14 09:52:18