Diabetes mellitus i fiziološka prilagodba na visoke koncentracije glukoze u krvi kod životinja

undergraduate thesis

• Title (english): Diabetes mellitus and physiological adaptation to high blood glucose levels in animals
• Author: Ena Španić
• Mentor: Duje Lisičić (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2016, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Dijabetes je bolest koja se razvija uslijed poremećaja metabolizma ugljikohidrata, masti i bjelančevina. Bolest karakteriziraju povišene koncentracije glukoze u krvi koje dovode do ozbiljnih komplikacija u organizmu. Upotrebom inzulina uspješno se kontroliraju razine glukoze ali nije u potpunosti riješen problem nastanka komplikacija za čiji je razvoj potreban dugi niz godina. U tu svrhu znanstvenici predlažu ptice kao modelne organizme za istraživanje bolesti. Među kralježnjacima, ptice imaju najveće razine glukoze u krvi i unatoč tome nemaju nikakvih posljedica. Posjeduju mehanizme kojima se uspješno bore protiv štetnih utjecaja hiperglikemije. Daljnje istraživanje tih mehanizama moglo bi promijeniti perspektivu liječenja dijabetesa.

Abstract (english)

Diabetes is a disease that develops as a result of disorders in the metabolism of carbohydrates, lipids and proteins. Hyperglycaemia, or raised blood sugar, is a common effect of uncontrolled diabetes and over time leads to serious damage of many organ systems. Allthough insulin is quite effective in controling blood glucose levels, serious complications can still occurre. Scientists propose birds as animal models for diabetes research. Birds have the highest blood glucose levels among the vertebrates, but without any consequences. They possess mechanisms that prevent development of complications caused by hyperglycemia. Further study of these mechanisms could change the perspective of diabetes treatment.

• Keywords: dijabetes; glukoza
• Keywords (english): diabetes; glucose
• Language: croatian
• URN:NBN: urn:nbn:hr:217:018205
• Study programme: Title: Environmental Sciences; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) struke znanosti o okolišu (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) struke znanosti o okolišu)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-01-04 10:04:59