Učinak retinoične kiseline na embrionalni razvoj sisavaca

undergraduate thesis

• Title (english): Impact of retinoic acid on embryonic development of mammals
• Author: Sanja Žalac
• Mentor: Gordana Lacković-Venturin (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2009, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Normalna morfogeneza embrija kralježnjaka je pod velikim utjecajem vanjskih doza retinoične kiseline. Uobičajeno, dovodi do kraniofacijalnih abnormalnosti i defekata srca te do deformacije udova. RA interferira s specifikacijom osnovice ektoderma i mezoderma tokom gastrulacije. Udovi u razvoju osjetljivi su i na manjak i na višak RA. Genetičke i biokemijske manipulacije pokazuju da su retinoidi neophodni za razvoj udova vertebrata u dva stadija: u ranoj organogenezi za začetak razvoja prednjih udova, te u srednjoj organogenezi za rast udova.

Abstract (english)

Normal morphogenesis of vertebrate embryos is severely affected by externally doses of retinoic acid. Typically it leads to craniofacial abnormalities and heart defects and to limb deformities. Limbs in development are sensitive to deficiency and excess of RA. Genetic and biochemical manipulations indicate that retinoids are crucial for vertebate limb development at two stages, in early organogenesis for forelimb bud initiation, and later in mid-organogenesis, for proper limb outgrowth.

• Keywords: retinoična kiselina; embrionalni razvoj sisavaca
• Keywords (english): retinoic acid; embryonic development of mammals
• Language: croatian
• URN:NBN: urn:nbn:hr:217:670860
• Study programme: Title: Molecular Biology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-03-21 13:00:20