Organizacija mikrotubula i diobenog vretena u stanicama bez centrosoma

undergraduate thesis

• Title (english): Organisation of microtubules and spindle pole in the cells without centosomes
• Author: Mirjana Polović
• Mentor: Dunja Leljak-Levanić (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2010, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Najvažnija komponenta stanice odgovorna za sastavljanje mikrotubula je gama tubulin. On potiče dimerizaciju alfa i beta tubulina i tako nastanak mikrotubula. Lokaliziran je naročito na površini jezgre biljnih stanica koja je otkrivena kao glavna mjesta sastavljanja mikrotubula. Također, kortikalna membrana i fragmoplast su mjesta na kojima se mikrotubuli sastavljaju. Visoka dinamika sastavljanja i rastavljanja mikrotubula vrlo je bitna kod diobe stanice kada se mikrotubuli intenzivno premještaju. Proteini povezani sa mikrotubulima imaju važnu ulogu u njihovoj stabilizaciji te pomažu sastavljanje mikrotubula. Buduća istraživanja bi trebala razjasniti molekularnu funkciju proteina koji potiču izduživanje mikrotubula na acentrosomalnim polovima i unutar diobenog vretena. Također, kontrolni mehanizmi koji reguliraju funkciju mikrotubulskih organizacijskih centara su još nedovoljno otkriveni.

Abstract (english)

The most improtant component of the cell, responsable for microtubule assembly is gammatubulin. Gamma-tubulin induce polimerisation of alpha and beta tubulin so as microtubule assembly. Its localized mostly on the nuclei surface, and this site is discovered as most active nucleating site of microtubules. Cortical membrane and phragmoplast are also sites of microtubule assembly. Highly dynamic assembly and dissasembly of microtubules is very important in mitosis when microtubules fast move in the cell. Proteins associated with microtubules are very important in stabilization of micortubules and for their assembly. Further researches should explain molecular function of proteins which induce polimerization of microtubules on acentrosomal poles and in mitotic spindle. Also, control points of regulation microtubule`s organization centers are still insufficient explained.

• Keywords: mikrotubul; diobeno vreteno
• Keywords (english): microtubules; spindle pole
• Language: croatian
• URN:NBN: urn:nbn:hr:217:164348
• Study programme: Title: Molecular Biology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-03-29 08:43:19