Hormolašci - iliti o molekulama koje ometaju hormonsko djelovanje

undergraduate thesis

• Title (english): Hormone disruptors – the molecules that mimic the hormones
• Author: Sanja Babić
• Mentor: Nenad Judaš (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2011, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Četrdesetih godina dvadesetog stoljeća nagla promjena ponašanja životinja izazvala je zabrinutost. Nakon dugotrajnih istraživanja dokazano je kako su uzrok hormolažci; spojevi koji zaustavljaju stvaranje ili pak blokiraju prijenos hormona u tijelu i tako narušavaju stanje organizma. Interekcijom s hormonima hormolašci negativno djeluju na endokrini, reprodukcijski, imunološki i neurološki sustav. Iako u početku nismo mogli predvidjeti negativne utjecaje spojeva koje smo sintetizirali, nismo ništa učinili kako bismo učili na greškama. I dalje proizvodimo tone tih spojeva, iako je više nego očita njihova gotovo identična struktura molekule. Sličan oblik molekule očito nikoga ne navodi na moguće slično djelovanje i interakciju s hormonima. Upravo zbog zanemarivanja više nego očitih činjenica, dopustili smo da ti kemijski spojevi odrede spol, ponašanje i zdravlje jedinki još u majčinoj utrobi. Dopustili smo da se rađaju djeca pod utjecajem DES-a, DDT-a, fenola i mnogih drugih hormolažaca koje još uvijek bezobzirno ispuštamo u okoliš i unosimo u organizam. Pošto je trenutno u prodaji više od 100 000 sintetskih spojeva od kojih su većina hormolažci, danas je nemoguće govoriti o trajnom rješenju. Trenutno je najvažnije širiti znanje i svjesnost o spojevima koji nam mogu otuđiti sve ono što nas čini individuom, što je ujedno i osnovni cilj ovog seminarskog rada.

Abstract (english)

A sudden change in animal behaviour caused concern in the 1940-ies. After long-lasting researches it was proven that it was caused by hormone disruptors; compounds which stop formation or block the transmission of hormones within the body and impair the condition of the organism. In interaction with hormones they have negative effect on the endocrine, reproductive, immune and the neurological system. Although in the beginning we weren't able to predict any negative effects of the compounds which we had synthesized, we didn't do anything to learn from our mistakes. We still produce tons of these compounds, although their molecule structures are obviously almost identical. Similar shape of a molecule obviously does not suggest to anyone that there might be similar action and interaction with hormones. Due to neglect of more than obvious facts, we allowed the chemical compounds to determine gender, behaviour and health of the individuals while still in the mother's womb. We allowed the birth of children under the influence of DES, DDT, phenol and many more hormone disruptors which are still recklessly released into the environment and entered into the organism. Today it is impossible to speak of a permanent solution since there are more than 100 000 synthetic compounds on sale and most of them are hormone disruptors. Currently, the most important thing is to broaden the knowledge and awareness of the compounds which can take away everything that makes us an individual, which is the main aim of this paper.

• Keywords: hormolašci
• Keywords (english): hormone disruptors
• Language: croatian
• URN:NBN: urn:nbn:hr:217:078921
• Study programme: Title: Ecology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-04-04 12:11:02