Makrofagni centri u jetri riba-histološki biomarkeri stresa

undergraduate thesis

• Title (english): Macrophage centers in fish liver-histological biomarkers of stress
• Author: Jure Krasić
• Mentor: Gordana Lacković-Venturin (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2013, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Ribe, zbog svojeg položaja u hranidbenom lancu, bioakumuliraju u organizmu velike količine zagađivača iz okoliša, zato ih se uzima kao najpogodnije biološke indikatore vodenih ekosustava. Melano-makrofagni centri su nakupine pigmentiranih stanica koje možemo naći kao dio strome hematopoetskog tkiva u slezeni, bubregu i jetri riba, gmazova i vodozemaca. Izgled melano-makrofagnih centara varira s obzirom na vrstu, i unutar vrste s obzirom na dob, veličinu, spol i fiziološko stanje jedinke, te temperaturu okoliša. Melano-makrofagni centri sadrže tri osnovne vrste pigmenata: melanin, lipofuscin i hemosiderin. Porijeklo i biokemijska uloga tih pigmenata nisu još poznate. Melano-makrofagni centri se smatraju filogenetskim prekursorima zametnih centara limfnih čvorova. Uzima se da je primarna uloga melano-makrofagnih centara uništenje, detoksikacija i recikliranje endogenih i egzogenih materijala. Melano-makrofagni centri se mogu uzeti kao indikatori zdravlja divljih populacija riba, jer se centri povećavaju u broju i veličini u upalnim procesima, oštećenjima tkiva i odgovorima na infekcije. Melano-makrofagni centri bi mogli biti korišteni kao senzitivni indikatori stresnih uvjeta u vodenim ekosustavima, zbog svojeg sudjelovanja u raznim procesima bolesti, gladovanja i izloženosti kemikalijama. Potrebno je obraćati pozornost na varijabilne parametre poput dobi, spola i veličine jedinke.

Abstract (english)

Fish, becauseof their position in the food chain, bioaccumulate in the body large amounts of pollutants from the environment, because of that they are regarded as the most suitable biological indicators of aquatic ecosystems. Melano-macrophage centers are clusters of pigmented cells that can be found as part of the stroma of hematopoietic tissue in the spleen, kidney and liver of fish, reptiles and amphibians. The appearanceof melano-macrophage centers varies according to species, and within species with respect to age, size, sex and physiological state ofan individual, and the ambient temperature. Melano-macrophage centers include three basic types of pigments: melanin, lipofuscin and hemosiderin. Origin and biochemicalrole of these pigments are not yet known. Melano-macrophage centers are considered phylogenetic precursors of embrionic centers of lymph nodes. It is assumed that the primary role of melano-macrophage centers is destruction, detoxification and recycling of endogenous and exogenic materials. Melano-macrophage centers can be taken as indicators of the health of wild fish populations, because the centers are increasing in number and size in inflammation, tissue damage and responses to infection. Melano-macrophage centers could be used as sensitive indicators of stress conditions in aquatic ecosystems, due to their participation in the various processes of disease, starvation and exposure to chemicals. It is necessary to pay attention to the variable parameters such as age, sex and size of specimens.

• Keywords: ribe; melano-makrofagni centri
• Keywords (english): fish; melano-macrophage centers
• Language: croatian
• URN:NBN: urn:nbn:hr:217:044758
• Study programme: Title: Molecular Biology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-04-24 10:17:41