Statističke metode za usporedbu profila oslobađanja lijeka

master's thesis

• Author: Ivan Čolić
• Mentor: Pavle Goldstein (mentor)
• Mentor: Drago Špoljarić (mentor)
• Committee member: Pavle Goldstein (predsjednik povjerenstva)
• Committee member: Drago Špoljarić (član povjerenstva)
• Committee member: Nikola Sandrić (član povjerenstva)
• Committee member: Marko Erceg (član povjerenstva)
• Granter: University of Zagreb; Faculty of Science; (Department of Mathematics); Zagreb
• Defense date and country: 2018-03-01, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Mathematics

Abstract

Jedna od tehnika usporedbe testnog i referentnog lijeka je usporedba brzine oslobađanja lijeka u nekom relevantnom mediju. U radu su opisane standardne statističke metode (metoda faktora, neparametarska metoda i parametarska metoda) za usporedbu profila oslobađanja testnog i referentnog lijeka. Primjenom metoda (koristeći programski jezik R) na različitim primjerima detaljnije je objašnjena njihova upotreba.

Abstract (english)

One of the techniques for comparison of a test and a reference drug is to compare a dissolution rate of drugs in some dissolution medium. In this thesis, we describe standard statistical methods (factor method, model independent method and model dependent method) for comparison between dissolution profiles of a test and a reference drug. By applying the methods (using programming language R) to different examples we are describing their application in detail.

• Keywords: brzina oslobađanja lijeka; metoda faktora; neparametarska metoda; parametarska metoda; programski jezik R
• Keywords (english): dissolution rate of drugs; factor method; model dependent method; model independent method; programming language R
• Language: croatian
• URN:NBN: urn:nbn:hr:217:917301
• Study programme: Title: Mathematical Statistics; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra matematike (magistar/magistra matematike)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-07-11 10:27:30