Biljni sekundarni metaboliti kao model za razvoj lijekova

undergraduate thesis

• Title (english): Plant secondary metabolites as a model for drug development
• Author: Vida Kufrin
• Mentor: Ivana Šola (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2018, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Biljni sekundarni metaboliti su spojevi koji nisu nužni za rast i razvoj biljaka, ali im omogućavaju prilagodbu i preživljavanje u okolišu. Strukturna kompleksnost i raznolikost sekundarnih metabolita osigurala im je važnu ulogu u farmaceutskoj industriji. Ovi spojevi koriste se u liječenju različitih medicinskih stanja kao što su tumori, neurodegenerativne bolesti, parazitske bolesti s naglaskom na malariju, metabolički poremećaji te glaukom. Biljni sekundarni metaboliti mogu biti izravno korišteni kao lijekovi za kliničku upotrebu, kao npr. galantamin, vinblastin i kinin. Sintetska optimizacija često je potrebna kako bi se povećala dostupnost samog spoja, u tom slučaju koriste se kao prototip za sintezu velikog broja strukturnih analoga koji mogu biti korišteni u razvoju lijekova. Dobri primjeri ovakve uporabe su paklitaksel, nitizinon i oseltamivir fosfat. Također, mogu biti korišteni i kao farmakološki i biokemijski alati u istraživanju mehanizama koji dovode do bolesti. Neki od spojeva korišteni u tu svrhu su genistein, kvercetin i forskolin.

Abstract (english)

Plant secondary metabolites are compounds not essential for plant growth and development, but are useful for adjustment and survival of plants in environment. Secondary metabolites structural complexity and diversity has ensured them an important role in pharmaceutical industry. Plant secondary metabolites are used for treatment of various medical conditions such as cancer, neurodegenerative diseases, parasitic diseases with emphasis on malaria, metabolic disorders and glaucoma. These compounds can be used directly as drugs in clinical use, like galantamine, vinblastine and quinine. Synthetic optimization is often required to increase bioavailability, in that case plant secondary metabolites serve as prototypes for the synthesis of high number of structural analogs that can be used in drug development. Good examples for such use are paclitaxel, nitisinone and oseltamivir phospate. Further, plant secondary metabolites can also serve as pharmacological and biochemical probes to help explain the mechanisms underlying human diseases. Some of the compounds used for this purpose are genistein, quercetin and forskolin.

• Keywords: Biljni sekundarni metaboliti; razvoj lijekova
• Keywords (english): Plant secondary metabolites; drug development
• Language: croatian
• URN:NBN: urn:nbn:hr:217:782817
• Study programme: Title: Molecular Biology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-10-01 10:42:26