Primjena CAR-T stanica u genskoj terapiji liječenja tumora

undergraduate thesis

• Title (english): Application of CAR-T cells in cancer gene therapy
• Author: Klara Krmpotić
• Mentor: Ivana Ivančić Baće (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2018, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Genska terapija predstavlja obećavajući terapijski alat za liječenje onih bolesti koje se konvencionalnim metodama liječenja nisu uspješno uspijele eliminirati. Otkrića u području humane genomike su, uz značajan tehnološki napredak, doprinijela njezinoj primjeni u liječenju širokog spektra bolesti. Unatoč mnogobrojnim provedenim istraživanjima i razvoju raznih potencijalnih terapija, rak je i dalje vodeći uzrok smrti u svijetu. Stoga je veliki broj kliničkih istraživanja, koja primjenjuju strategije genske terepije, usmjereno njegovoj redukciji i eliminaciji. Tijekom niza godina predložene su brojne strategije genske terapije tumora od kojih je većina bila klinički neuspješna. Međutim, tijekom posljednjih nekoliko godina, novi oblik imunoterapije zadobiva veliku pozornost u istraživanju uslijed visoke terapeutske učinkovitosti. Riječ je o terapiji CAR-T koja objedinjuje strategije genske terapije, stanične terapije i imunoterapije. Ovaj rad donosi kratki pregled nekih od glavnih strategija genske terapije u liječenja tumora s posebnim osvrtom na adaptivnu staničnu terapiju CAR-T. Također, u radu su izloženi nedostaci i štetne nuspojave, kao i strategije razvoja sigurnije i učinkovitije terapije.

Abstract (english)

Gene therapy is a promising therapeutic tool for the treatment of diseases not eliminated by conventional treatment methods. Discoveries in the field of human genomics have, along with the significant technological advances, contributed to its application in the treatment of a wide range of diseases. Despite numerous studies and development of variety potential therapies, cancer remains the leading cause of death in the world. Therefore, a large number of clinical studies, that apply gene therapy strategies, are directed towards its reduction and elimination. Over the course of many years, a number of cancer gene therapy strategies have been proposed, most of which were clinically unsuccessful. However, over the last few years, a new form of immunotherapy has gained great attention in research due to high therapeutic efficacy. Therapy in question is CAR-T therapy that combines gene therapy, cell therapy and immunotherapy strategies. This paper provides a brief overview of some of the major gene therapy strategies for cancer treatment, with a special focus on adaptive CAR-T therapy. Also, the paper presents disadvantages and adverse side effects, as well as strategies for developing safer and more effective therapy.

• Keywords: genska terapija; tumor; imunoterapija; terapija CAR-T
• Keywords (english): gene therapy; cancer; immunotherapy; CAR-T therapy
• Language: croatian
• URN:NBN: urn:nbn:hr:217:908709
• Study programme: Title: Molecular Biology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-10-02 09:20:38