Istraživanje mehanokemijske sinteze kokristala in situ Ramanovom spektroskopijom

master's thesis

• Title (english): Mechanochemical cocrystal formation studied by in situ Raman spectroscopy.
• Author: Stipe Lukin
• Mentor: Ivan Halasz (mentor)
• Committee member: Josip Požar (predsjednik povjerenstva)
• Committee member: Ivica Đilović (član povjerenstva)
• Committee member: Branimir Bertoša (član povjerenstva)
• Granter: University of Zagreb; Faculty of Science; (Department of Chemistry); Zagreb
• Defense date and country: 2016-07-08, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry

Abstract

U ovom radu mehanokemijskom sintezom u suhim uvjetima i tekućinom potpomognutim mljevenjem dobiveni su kokristali nikotinamida s benzojevom, antranilnom ili salicilnom kiselinom. Kokristali s antranilnom i benzojevom kiselinom dosad nisu bili poznati u literaturi i okarakterizirani su uz pomoć difrakcije rendgenskih zraka na praškastim uzorcima i uz pomoć Ramanove spektroskopije. Kristalne strukture dosad nepoznatih kokristala određene su iz difrakcijskih podataka. In situ Ramanovom spektroskopijom praćene su sve reakcije, a istraţio se i utjecaj dodatka male količine primarnih alkohola na brzinu i tijek reakcije.

Abstract (english)

In this thesis neat grinding and liquid-assisted grinding procedures for mechanochemical synthesis of cocrystals of nicotinamide with benzoic, anthranillic or salicylic acid were investigated. Obtained cocrystals of nicotinamide with benzoic or anthranillic acid were not previously known in the literature and were charachterized using powder X-ray diffraction and Raman spectroscopy. Crystal structures were solved using powder X-ray diffraction data. In situ Raman spectroscopy was used to gain insights into the course of the reaction including the influence of small quantities of added alcohols.

• Keywords: kokristali; in situ Ramanova spektroskopija; suho mljevenje; nikotinamid; benzojeva kiselina; antranilna kiselina; salicilna kiselina
• Keywords (english): cocrystal; in situ Raman spectroscopy; neat grinding; nicotinamide; benzoic acid; anthranilic acid; salicylic acid
• Language: croatian
• URN:NBN: urn:nbn:hr:217:200111
• Study programme: Title: Graduate Studies in Chemistry; specializations in: Research (scientific-professional) programme; Course: Research (scientific-professional) programme; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2017-01-26 13:26:30