Neuroimunomodularni učinak Toxoplasme gondii u shizofreniji

doctoral thesis

• Title (english): Neuroimmunomodulatory effect of Toxoplasma gondii in schizophrenia
• Author: Suzana Vlatković
• Mentor: Dubravka Švob Štrac (mentor)
• Committee member: Julija Erhardt (predsjednik povjerenstva)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2018-09-26, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology
• Universal decimal classification (UDC): 57 - Biological sciences. Physical anthropology. Biodiversity

Abstract

Složena etiologija i biološka podloga shizofrenije te skromne spoznaje o utjecaju infekcija na
razvoj ove bolesti, potaknule su ovo istraživanje neuroimunomodulatornog učinka parazita
Toxoplasma gondii (TG) u shizofreniji. Rezultati upućuju da TG seropozitivni bolesnici imaju
težu kliničku sliku bolesti, karakteriziranu većim brojem bolničkih liječenja, dužim
psihijatrijskim tretmanom i češćom refrakternošću na terapiju. Međutim, TG seropozitivni
bolesnici, usprkos starije dobi i češćeg uzimanja atipičnih antipsihotika, imaju nižu
koncentraciju triglicerida, omjer triglicerida i lipoproteina visoke gustoće (HDL), opseg bokova
i tjelesnu težinu, te posljedično i manji rizik razvoja kardiovaskularnih bolesti. U našem
istraživanju nisu utvrđene statistički značajne razlike u koncentraciji trombocitnog serotonina i
aktivnosti trombocitne monoaminooksidaze tipa B (MAO-B), kao niti u koncentraciji C
reaktivnog proteina (CRP-a) i interleukina 6 (IL-6) između TG seropozitivnih i TG
seronegativnih ispitanika sa shizofrenijom. Stoga su potrebna daljna istraživanja koja će
dodatno razjasniti povezanost infekcije sa TG i razvoja shizofrenije.

Abstract (english)

Complex etiology and biological basis of schizophrenia, and modest knowledge regarding
effects of infections on its development, stimulated this study of Toxoplasma gondii (TG)
neuroimmunomodulatory effect in schizophrenia. Results suggest that TG seropositive patients
have more severe clinical presentation, with higher number of hospitalisations, longer
psychiatric treatment and more frequent treatment-resistance. However, TG seropositive
patients, despite older age and more frequent usage of atypical antipsychotics, had lower
triglyceride concentration, triglyceride/high-density lipoprotein cholesterol (HDL-C) ratio, hip
circumference and body weight, suggesting lower risk for cardiovascular disease. No
differences in concentrations of platelet serotonin levels and higher platelet monoamino oxidase
type B (MAO-B) activity, as well as of C-reactive protein (CRP) and interleukin-6 (IL-6) levels
between TG seropositive and TG seronegative subjects with schizophrenia were found. Further
research is needed to further clarify the association between TG infection and development of
schizophrenia.

• Keywords: shizofrenija; Toxoplasma gondii; serotonin; MAO-B; citokini; metabolički pokazatelji; terapijska rezistencija; bihevioralne osobine
• Keywords (english): schizophrenia; Toxoplasma gondii; serotonin; MAO-B; cytokines; metabolic indices; refractory; behavioral properties
• Language: croatian
• URN:NBN: urn:nbn:hr:217:011792
• Study programme: Title: Biology; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija (doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access; Embargo expiration date: 2020-09-26
• Created on: 2018-10-15 11:41:38