Genotoksični učinak farmaceutika na školjkaše

undergraduate thesis

• Title (english): Genotoxic effects of pharmaceuticals on bivalves
• Author: Petra Petrina
• Mentor: Mirjana Pavlica (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2019, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Farmaceutici su raznolika skupina spojeva koji se koriste u svrhu liječenja te prevencije
bolesti u ljudi, ali se koriste i u veterini, akvakulturi i stočarstvu. Mjerljive koncentracije ovih
spojeva izmjerene su u površinskim vodama diljem svijeta, zbog čega lijekovi i proizvodi za
osobnu njegu (PPCP) odnedavno postaju predmetom njihovog istraživanja kao okolišnih
zagađivača. Kada se takvi spojevi nađu u okolišu, mogu djelovati na usporedljive biokemijske
mehanizme drugih organizama koji nisu bili njihova ciljana meta. Zbog razlika u fiziologiji,
ovakvi spojevi mogu biti vrlo toksični za beskralježnjake.
U ovom radu obrađen je učinak četiriju često detektiranih farmaceutika u vodenim
okolišima, fluoksetina, triklosana, paracetamola i ibuprofena, na školjkaše. Sva četiri
spomenuta spoja imaju genotoksični učinak na hemocite školjkaša pri višim koncentracijama.
Štetni učinci ovih spojeva mogu se pratiti i pri znatno nižim, okolišnim koncentracijama. Zbog
činjenice da farmaceutici opstaju u vodi i nakon njenog pročišćavanja, najugroženije zajednice
organizama su upravo one koje žive u blizini postrojenja za obradu otpadnih voda.

Abstract (english)

Pharmaceuticals are a diverse group of chemicals that are used for treating and
preventing diseases in people, but are also used in veterinary medicine, aquaculture and
agriculture. Measurable concentrations of certain pharmaceuticals have been found in surface
waters all over the world, which is why pharmaceuticals and personal care products (PPCSs)
are recently being investigated as environmental pollutants. When these chemicals end up in
the environment, they can affect comparable pathways of non-target organisms. Due to
differences in physiology, these molecules can be highly toxic for invertebrates.
In this work, the effect of widely used pharmaceuticals on bivalves was reviewed. All
four of mentioned pharmaceuticals, fluoxetine, triclosan, paracetamol and ibuprofen have
shown a genotoxic effect on bivalve haemocytes. Harmful effects of these pharmaceuticals can
be detected even at environmental concentrations. Due to the persistence of pharmaceuticals
after wastewater treatments, the most vulnerable populations of organisms are those living near
wastewater treatment plants.

• Keywords: školjkaši; farmaceutici
• Language: croatian
• URN:NBN: urn:nbn:hr:217:516767
• Study programme: Title: Environmental Sciences; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) struke znanosti o okolišu (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) struke znanosti o okolišu)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2019-10-25 07:36:59