Start/stop Codon-like Trinucleotides (CLTs) and Extended Clusters as New Language of DNA

Scientific paper - Preliminary note / Short communication

• Author: Marija Rosandić
• Author: Matko Glunčić
• Author: Vladimir Paar
• Author's institution: University of Zagreb; Faculty of Science; (Department of Physics)
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Physics

Abstract (english)

DNA nucleotide sequences carry genetic information of different kinds, not just coding instructions for protein synthesis. They can play a role, for example, in alternative conformations and gene regulators. The present paper introduces the extended start/stop codon-like trinucleotides (CLTs) for noncoding DNA sequences, based on trinucleotide cluster extension generated by specific single-nucleotide multiplications. Extended cluster analysis gives rise to rich information potential as a "new language" of DNA ("CLT-language"). The analysis of start/stop-CLTs extended clusters provides qualitative and quantitative differentiation and characterization of alpha satellites, as well as of other repetitive and non-repetitive noncoding sequences. As a measure of CLT extension of DNA sequences the extension factor r is introduced. Start/stop CLTs enable a distinction of three segments within alpha satellite, the first and the second as wrapping sequences and the third as a linker. Within a linker there are no start/stop CLTs. On the basis of start/stop-CLTs, it is hypothesized that these noncoding sequences may be involved in the networks of gene regulators.

• Keywords (english): alpha satellites; start/stop codons; nucleosome; cluster extension; gene regulators
• Language: english
• Publication type: Scientific paper - Preliminary note / Short communication
• Publication status: Published
• Peer review: Peer review - international
• Publication version: Published version
• Journal title: Croatica Chemica Acta
• Numbering: vol. 84, no. 2, pp. 334-341
• p-ISSN: 0011-1643
• e-ISSN: 1334-417X
• DOI: https://doi.org/10.5562/cca1948
• URN:NBN: urn:nbn:hr:217:097023
• Publication: 2011
• Project: Number: 119-0982464-1253; Title (croatian): KSA kompjutorsko istraživanje repeticija višeg reda i duplikona u humanom genomu; Leader: Vladimir Paar; Jurisdiction: Croatia; Funding stream: ZP
• Document URL: https://hrcak.srce.hr/71995
• Type of resource: Text
• Access conditions: Open access
• Created on: 2019-11-03 17:56:31