Povezanost sastava ljudske crijevne mikrobiote i epilepsije

undergraduate thesis

• Title (english): Correlation between human gut microbiota and epilepsy
• Author: Roberto Galov
• Mentor: Martina Šeruga Musić (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2022-09-19, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Poznato je da os mikrobiota-crijeva-mozak ima velik utjecaj na mozak i mentalno
zdravlje. Posljednjih godina se utjecaj ove osi i sastava crijevne mikrobiote na epilepsiju sve više
istražuje. Postoje mnogi dokazi interakcije mikrobiote i mozga koji, kao rezultat, imaju pozitivne
i negativne utjecaje na učestalost i intenzitet epileptičkih napadaja. Točni mehanizmi ovih
interakcija još uvijek se pokušavaju razjasniti. Ovaj rad predstavlja pregled do sada poznatih
saznanja o utjecaju crijevne mikrobiote na epilepsiju, mogućim putevima komunikacije crijeva i
mozga i potencijalnim alternativnim terapijama za epilepsiju alteracijom sastava crijevne
mikrobiote. Takve terapije uključuju primjenu antibiotika, probiotika, određene promjene u
prehrani i transplantaciju mikrobiote. Predložene su i mjere koje bi se mogle poduzeti da
istraživanja na ovu temu u budućnosti daju bolje i pouzdanije rezultate.

Abstract (english)

It is a well known fact that microbiome-gut-brain axis has an effect on human brain and
mental health. Over the last couple of years, an increasing number of studies are conducted
regarding the effect this axis and gut microbiome composition has on epilepsy. There is a great
deal of evidence that demonstrate positive and negative impacts of gut-brain interaction on the
frequency and intensity of epileptic seizures. The exact mechanisms underlying these interactions
still remain to be completely deciphered. This paper presents a review of known evidence
regarding the effect microbiome has on epilepsy, communication pathways between gut and brain
as well as potential alternative epilepsy treatments by altering gut microbiome composition.
These treatments include the use of antibiotics, probiotics, dietary restrictions and microbiome
transplants. This paper also recommends certain measures for future reasarch on this subject that
can yield better and more reliable results.

• Keywords: epilepsija; mikroflora; disbioza; živac vagus; keto dijeta
• Keywords (english): epilepsy; microflora; dysbiosis; vagus nerve; ketogenic diet
• Language: croatian
• URN:NBN: urn:nbn:hr:217:600936
• Study programme: Title: Ecology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-10-04 13:03:25