Razvoj mRNA cjepiva

undergraduate thesis

• Title (english): The Development of mRNA Vaccines
• Author: Luka Buršić
• Mentor: Ivana Ivančić Baće (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2022-09-12, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Suprotno čestom mišljenju, tehnologija koja stoji iz mRNA cjepiva nije stvorena nedavno. Ta
iznenađujuće jednostavna tehnologija nije se primjenjivala u ljudskoj medicini zbog predrasude
od nestabilnosti molekule RNA. Ipak, nakon godina istraživanja unosa molekula RNA lipidnim
nanočesticama, koja su prvenstveno bila okrenuta prema RNA-ovisnom utišavanju gena,
nakupila su se saznanja koja su u situaciji pandemije COVID-19 mogla biti iskorištena za razvoj
prvih mRNA cjepiva namijenjenih ljudima. Poboljšanja u sintezi molekula RNA, u
razumijevanju imunosnog odgovora induciranog sintetskim molekulama RNA, u sintezi
raznolikih lipida za nanočestice i u sintezi samih nanočestica razlog su zašto je mRNA
tehnologija (cjepiva i terapeutici), premda jednostavna, uspješna i sigurna za uporabu.

Abstract (english)

Opposite of what is commonly thought, mRNA vaccines are not a recently developed
technology. This surprisingly simple technology wasn’t of use in human medicine just because
of the prejudice of the instability of RNA molecule. Nevertheless, after years of research on
cell's intake of RNA molecules.by lipid nanoparticles, primarily conducted for RNA-induced
gene silencing, knowledge kept growing until the time of COVID-19 pandemics when it was
finally used to give rise to the first mRNA vaccine for humans. Optimizing RNA synthesis,
understanding RNA-induced immune response, optimizing synthesis of various lipids and lipid
nanoparticle are the reason why mRNA technology (vaccines and therapeutics), although
simple, is efficient and safe to use.

• Keywords: prevencija; RNA tehnologija; nanočestice; imunologija; cjepiva
• Keywords (english): prevention; RNA technology; nanoparticles; immunology; vaccine
• Language: croatian
• URN:NBN: urn:nbn:hr:217:653686
• Study programme: Title: Molecular Biology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-10-10 11:10:53