Mehanokemijska sinteza koordinacijskih kompleksa bakra(II) s aminokiselinama s alifatskim bočnim ograncima

master's thesis

• Title (english): Mechanochemical synthesis of coordination compounds of copper(II) with amino acids containing aliphatic side chains
• Author: Katarina Laća
• Mentor: Ivica Đilović (mentor)
• Committee member: Ivica Đilović (predsjednik povjerenstva)
• Committee member: Iva Juranović Cindrić (član povjerenstva)
• Committee member: Ines Primožič (član povjerenstva)
• Committee member: Jana Pisk (član povjerenstva)
• Granter: University of Zagreb; Faculty of Science; (Department of Chemistry); Zagreb
• Defense date and country: 2023-03-31, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry

Abstract

U sklopu diplomskog rada ispitani su mehanokemijski postupci sinteze koordinacijskih
spojeva bakra(II) i aminokiselina s alifatskim bočnim ograncima. Koristeći LAG metodu,
odnosno otapalom potpomognuto mljevenje, uspješno su pripravljeni koordinacijski spojevi
Cu(L-Ala)2, Cu(L-Leu)2, Cu(L-Ile)2, Cu(L-Val)2, Cu(L-Pro)2 i ternarni spojevi Cu(L-Ala)(L-Ile)
i Cu(L-Ala)( L-Val). Prilikom sinteza ternarnih spojeva, u 8 od 10 sinteza su dobiveni
koordinacijski spojevi bakra s istovrsnim aminokiselinama, što ukazuje na selektivnost Cu(II)
iona prema aminokiselinama, koja prati sljedeći trend: L-Leu ≈ L-Pro > L-Ile ≈ L-Val > L-Ala.
Produkti su karakterizirani koristeći spektroskopiju IR (tehnika ATR) i rendgensku difrakciju
u polikristalnom uzorku. Produkti trans-Cu(L-Val)2 i cis-Cu(L-Ile)2(H2O) su karakterizirani i
rendgenskom difrakcijom na monokristalnom uzorku te su određene molekulske i kristalne
strukture. U slučaju trans-bis(L-valinato)bakra(II), metalni centar ima oktaedarsku
koordinaciju uz deformaciju geometrije što je posljedica Jahn-Tellerovog efekta. Kod cisbis(L-izoleucinato)bakra(II) je metalni centar pentakoordiniran te je geometrija kvadratno
piramidalna.

Abstract (english)

This diploma thesis presents an investigation of mechanochemical synthesis of coordination
compounds of copper(II) and amino acids containing aliphatic side chains. Using the LAG
method (liquid assisted grinding), the following compounds were successfully obtained:
Cu(L-Ala)2, Cu(L-Leu)2, Cu(L-Ile)2, Cu(L-Val)2, Cu(L-Pro)2, Cu(L-Ala)( L-Ile) and
Cu(L-Ala)(L-Val). When trying the synthesis of ternary compounds, coordination compounds
of copper with identical amino acids were obtained in 8 out of 10 syntheses, which indicates
the selectivity of Cu(II) ions towards amino acids, which follows the trend: L-Leu ≈ L-Pro >
L-Ile ≈ L-Val > L-Ala. Obtained complexes were identified using IR spectroscopy (ATR
technique) and powder X-ray diffraction. Molecular and crystal structures of trans-Cu(L-Val)2
and cis-Cu(L-Ile)2(H2O) were deermined using single crystal X-ray diffraction. Jahn-Teller
effect was noticed as the geometry of copper ion in trans-Cu(L-Val)2 is distorted octahedral,
whereas in the case of cis-Cu(L-Ile)2(H2O) the copper ion is pentacoordinated and the
geometry is square pyramidal.

• Keywords: aminokiseline; bakar(II); L-alanin; L-izoleucin; L-leucin; L-prolin; L-valin; mehanokemijski postupci sinteze
• Keywords (english): copper(II); L-alanine; L-isoleucine; L-leucine; L-proline; L-valine; mechanochemical synthesis
• Language: croatian
• URN:NBN: urn:nbn:hr:217:701316
• Study programme: Title: Graduate university studies in chemistry; specializations in: Research programme; Course: Research programme; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Embargoed access; Embargo expiration date: 2025-03-31
• Created on: 2023-04-04 12:09:42