Utjecaj endokrinih disruptora na neurorazvoj

undergraduate thesis

• Title (english): The influence of endocrine disruptors on neurodevelopment
• Author: Dora Matija Antonina
• Mentor: Vesna Benković (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2023-09-22, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Poznato je da izloženost endokrinim disruptorima može imati kobne zdravstvene posljedice jer
njihova ingestija ili apsorpcija dovodi do promjene aktivnosti hormona i poremećaja
endokrinog sustava, što posljedično nosi štetne učinke na zdravlje organizma, njegovog
potomstva ili (sub)populacije. Posljednjih se godina sve više istražuju endokrini disruptori s
neurotoksičnim djelovanjem i njihov utjecaj na neurorazvoj. Ovu vezu potvrđuju brojne in vivo
i in vitro studije, čiji je fokus pretežno na značajkama poremećaja iz spektra autizma (ASD) i
poremećaja pažnje i hiperaktivnosti (ADHD). Te studije ukazuju na to kako bi prenatalna
izloženost određenim endokrinim disruptorima mogla biti povezana s etiologijom ovih i njima
sličnih neurorazvojnih poremećaja. Iako točni biokemijski mehanizmi zaslužni za ove
interakcije nisu u potpunosti razjašnjeni, poznato je da endokrini disruptori najčešće dovođeni
u vezu s neurorazvojnim poremećajima uključuju organofosfatne pesticide, polibromirane
difeniletere (PBDE-i), poliklorirane bifenile (PCB-i) i bisfenol A (BPA). Ovaj rad predstavlja
pregled do sada poznatih saznanja o utjecaju navedenih endokrinih disruptora na neurorazvoj.

Abstract (english)

Exposure to endocrine disruptors (EDs) is known to have caused fatal health problems due to
their ingestion or absorption leading to changes in hormone activity. Disruption of the
endocrine system has adverse effects on an organism’s health, its offspring or (sub)population.
Over the last years, an increasing number of studies has been conducted regarding the effect
certain neurotoxic EDs tend to have on neurodevelopment. This link is confirmed by numerous
in vivo and in vitro studies, which focused predominantly on autism spectrum disorder (ASD)
and attention deficit hyperactivity disorder (ADHD). These studies indicate that prenatal
exposure to certain EDs could be related to the etiology of these and similar
neurodevelopmental disorders. Although the exact mechanisms underlying these interactions
still remain to be deciphered, it is known that EDs associated with neurodevelopmental
disorders include organophosphate pesticides, polybrominated diphenyl ethers (PBDEs),
polychlorinated biphenyls (PCBs) and bisphenol A (BPA). This paper presents an overeview
of known evidence regarding the effect mentioned chemicals have on neurodevelopment.

• Keywords: ASD; ADHD; endokrini sustav; BPA; PCB; PBDE
• Keywords (english): ASD; ADHD; endocrine system; BPA; PCB; PBDE
• Language: croatian
• URN:NBN: urn:nbn:hr:217:138218
• Study programme: Title: Ecology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-10-02 12:30:30