Učinak esencijalnih ulja mirte(Myrtuscommunis L.) i lovora (Laurus nobilisL.)naaterogene indekse uštakora

master's thesis

• Title (english): Effect of essential oils frommyrtle(Myrtuscommunis L.) and laurel (Laurus nobilisL.)on atherogenic indices inrats
• Author: Jerko Kanić
• Mentor: Nada Oršolić (mentor)
• Mentor: Dyana Odeh (mentor)
• Committee member: Nada Oršolić (predsjednik povjerenstva)
• Committee member: Dyana Odeh (član povjerenstva)
• Committee member: Duje Lisičić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2023-09-20, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Bolesti krvožilnog sustava (KVB) odgovorne su za približno 50% ukupne godišnje smrtnosti, međukojima je i ateroskleroza. Čimbenici rizika za KVB, uključujući dislipidemiju, hipertenziju, dijabetes, pušenje, infekcije i prekomjernu tjelesnu težinu uzrokuju oksidacijski stres koji oštećuje funkcijukrvožilnog endotela vodeći do kronične, progresivne, upalne bolesti karakterizirane stvaranjemzadebljanja (ateroma) u unutarnjim slojevima arterijske stijenke. Ljekovite biljke se koriste već tisućamagodina u narodnoj medicini za liječenje brojnih bolesti uključujući bolesti krvožilnog sustava. Cilj ovograda bio je istražiti mogućnost primjene esencijalnih ulja (EO) lovora (Laurus nobilis L.) i mirte (Myrtuscommunis L.) u zaštiti i liječenju bolesti krvožilnog sustava kroz praćenje težine životinja, antioksidacijskih, antilipidemijskih i aterogenih pokazatelja štakora. Rezultati pokazuju da intragastričnaprimjena EO lovora i mirte tijekom dva tjedna utječe na gubitak tjelesne težine štakora, smanjenjeglikolitičke aktivnosti i lipidnih parametara (kolesterol, trigliceridi, LDL-c, VLDL-c) te smanjenjeaterogenih pokazatelja vodeći zaštiti krvožilnog sustava. Jedan od čimbenika koji pridonosi zaštiti
krvožilnog sustava jest antioksidacijski potencijal EO lovora i mirte.

Abstract (english)

Cardiovascular diseases (CVD) are responsible for approximately 50% of total annual mortality, amongwhich is atherosclerosis. Risk factors for CVD, including dyslipidemia, hypertension, diabetes, smoking, infections, and excess body weight cause oxidative stress that impairs vascular endothelial functionleading to a chronic, progressive, inflammatory disease characterized by the formation of thickening(atheroma) in the inner layers of the arterial wall. Medicinal plants have been used for thousands of yearsin folk medicine for the treatment of numerous diseases, including diseases of the circulatory system. Theaim of this work was to investigate the possibility of using essential oils (EO) of laurel (Laurus nobilis L.)
and myrtle (Myrtus communis L.) in the protection and treatment of cardiovascular diseases by monitoringthe weight of animals, antioxidant, antilipidemic and atherogenic parameters of rats. The results showthat
the intragastric application of laurel and myrtle EO for two weeks affects the loss of body weight inrats, the reduction of glycolytic activity and lipid parameters (cholesterol, triglycerides, LDL-c, VLDL-c) andthe reduction of atherogenic indicators leading to the protection of the cardiovascular system. One of thefactors that contributes to the protection of the circulatory system is the antioxidant potential of laurel andmyrtle EO

• Keywords: ateroskleroza; esencijalna ulja; antioksidacijski i lipidni parametr
• Keywords (english): atherosclerosis; essential oils; antioxidative and lipid parameters
• Language: croatian
• URN:NBN: urn:nbn:hr:217:796831
• Project: Number: KK.01.1.1.04.0093; Title: Bioaktivne molekule ljekovitog bilja kao prirodni antioksidansi, mikrobiocidi i konzervansi; Title: Medicinal plants' bioactive molecules as natural antioxidants, microbicides and preservatives; Leader: Verica Dragović-Uzelac; Jurisdiction: Croatia; Funder: EK; Funding stream: KF
• Study programme: Title: Experimental Biology; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra eksperimentalne biologije (magistar/magistra eksperimentalne biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Embargoed access; Embargo expiration date: 2025-09-20
• Created on: 2023-10-02 13:01:06