Gama-radiolitička razgradnja loratadina u vodi

master's thesis

• Title (english): Gamma-radiolytic degradation of loratadine in water
• Author: Natalija Tunjko
• Mentor: Nives Galić (mentor)
• Mentor: Ivana Tartaro Bujak (mentor)
• Committee member: Nives Galić (predsjednik povjerenstva)
• Committee member: Jana Pisk (član povjerenstva)
• Committee member: Tajana Begović (član povjerenstva)
• Committee member: Ivan Nemet (član povjerenstva)
• Granter: University of Zagreb; Faculty of Science; (Department of Chemistry); Zagreb
• Defense date and country: 2024-02-21, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry

Abstract

Loratadin je antihistaminik koji se zbog česte upotrebe može pojaviti u otpadnim vodama što predstavlja rastući rizik za okoliš. Primjena ionizirajućeg zračenja pokazala se kao dobra alternativna metoda pročišćavanja otpadnih voda. U ovom radu provedena je razgradnja loratadina primjenom gama-zračenja. Utjecaj brzine i doze zračenja, te prisutnost različitih anorganskih soli i hvatača radikala na učinkovitost razgradnje određena je tekućinskom kromatografijom visoke djelotvornosti. Razgradni produkti analizirani su vezanim sustavom tekućinske kromatografije ultravisoke djelotvornosti i spektrometrije masa visokog razlučivanja. Na temelju MS i MS/MS spektara predložene su njihove strukture i razgradni put loratadina.

Abstract (english)

Loratadine is an antihistamine which, because of the frequent use, can be found in wastewater, presenting a growing environmental risk. Ionizing radiation was found to be an effective alternative wastewater purification method. In this work degradation of loratadine by gamma irradiation was performed. The efficiency of degradation at different radiation rates and doses, in the presence of various inorganic salts and radical scavengers was investigated by high performance liquid chromatography. The degradation products were analysed by ultra high-performance liquid chromatography coupled to high-resolution mass spectrometry. Structures of degradants and degradation pathway of loratadine were proposed based on obtained results.

• Keywords: gama-zračenje; loratadin; razgradni produkti; spektrometrija masa
• Keywords (english): degradation products; gamma irradiation; loratadine; mass spectrometry
• Language: croatian
• URN:NBN: urn:nbn:hr:217:969504
• Study programme: Title: Graduate university studies in chemistry; specializations in: Graduate university studies in chemistry; Course: Graduate university studies in chemistry; Study programme type: university; Study level: graduate; Academic / professional title: sveučilišni/a magistar/magistra kemije (sveučilišni/a magistar/magistra kemije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Embargoed access; Embargo expiration date: 2026-02-21
• Created on: 2024-03-04 11:47:56