Mehanokemijska sinteza i karakterizacija inkluzijskog kompleksa loratadina i hidroksipropil-β-ciklodekstrina

master's thesis

• Title (english): Mechanochemical synthesis and characterization of hydroxypropyl-β-cyclodextrin inclusion complex with loratadine
• Author: Mateja Cader
• Mentor: Nives Galić (mentor)
• Mentor: Dominik Cinčić (mentor)
• Committee member: Nives Galić (predsjednik povjerenstva)
• Committee member: Dominik Cinčić (član povjerenstva)
• Committee member: Nikola Cindro (član povjerenstva)
• Committee member: Nikola Bregović (član povjerenstva)
• Committee member: Vladimir Stilinović (član povjerenstva)
• Granter: University of Zagreb; Faculty of Science; (Department of Chemistry); Zagreb
• Defense date and country: 2024-02-16, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry

Abstract

Loratadin (LOR) je antihistaminik niske topljivosti. Međutim, poznato je da mu se topljivost povećava kompleksiranjem s ciklodekstrinima.U ovom radu ispitana je mogućnost priprave inkluzijskog kompleksa loratadina i (2-hidroksipropil)-β-ciklodekstrina mljevenjem u mlinu bez i uz dodatak male količine organskog otapala, te u različitim stehiometrijskim omjerima loratadina i ciklodekstrina. Pripremljeni uzorci analizirani su infracrvenom spektroskopijom, razlikovnom pretražnom kalorimetrijom i difrakcijom rendgenskog zračenja na praškastom uzorku. Dobivenim produktima i čistom loratadinu određena je topljivost u vodi i biorelevantnim medijima (pH 4,5 i 6,8) UV/VIS spektroskopijom i tekućinskom kromatografijom visoke djelotvornosti.

Abstract (english)

Loratadine (LOR) is a low-solubility antihistamine. However, it is known that its solubility increases through complexation with cyclodextrins. In this study, the possibility of preparing an inclusion complex of loratadine and (2-hydroxypropyl)-β-cyclodextrin was examined by grinding in a mill with and without the addition of a small amount of organic solvent, and in various stoichiometric ratios of loratadine and cyclodextrin. The prepared samples were analysed by infrared spectroscopy, differential scanning calorimetry, and X-ray powder diffraction. The solubility of the obtained products and pure loratadine was determined in water and biorelevant media (pH 4.5 and 6.8) using UV/VIS spectroscopy and high-performance liquid chromatography.

• Keywords: ciklodekstrini; inkluzijski kompleksi; loratadin; mehanokemijska aktivacija; topljivost
• Keywords (english): cyclodextrins; complex characterization; inclusion complexes; loratadine; mechanochemical synthesis; solubility.
• Language: croatian
• URN:NBN: urn:nbn:hr:217:536794
• Project: Number: IP-2022-10-6033; Title: Priprava, karakterizacija i biokompatibilnost novih supramolekulskih kompleksa lijek/ciklodekstrin i lijek/dekstrinske nanospužve s poboljšanim svojstvima; Title: Preparation, characterization and biocompatibility studies of novel drug/cyclodextrin and drug/dextrin-based nanosponge supramolecular complexes with enhanced functionality; Acronym: DrugCD.com; Leader: Nives Galić; Jurisdiction: Croatia; Funder: Hrvatska zaklada za znanost; Funding stream: Research Projects
• Study programme: Title: Graduate university studies in chemistry; specializations in: Graduate university studies in chemistry; Course: Graduate university studies in chemistry; Study programme type: university; Study level: graduate; Academic / professional title: sveučilišni/a magistar/magistra kemije (sveučilišni/a magistar/magistra kemije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Embargoed access; Embargo expiration date: 2025-02-16
• Created on: 2024-03-05 14:30:13