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Scientific paper - Original scientific paper
An Explanation of Exceptions from Chargaff’s Second Parity Rule/Strand Symmetry of DNA Molecules
Genes, 13 (2022), 11; 1929. https://doi.org/10.3390/genes13111929
Rosandić, Marija; Vlahović, Ines; Pilaš, Ivan; Glunčić, Matko; Paar, Vladimir

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Rosandić, M., Vlahović, I., Pilaš, I., Glunčić, M. & Paar, V. (2022). An Explanation of Exceptions from Chargaff’s Second Parity Rule/Strand Symmetry of DNA Molecules. Genes, 13. (11). doi: 10.3390/genes13111929

Rosandić, Marija, et al. "An Explanation of Exceptions from Chargaff’s Second Parity Rule/Strand Symmetry of DNA Molecules." Genes, vol. 13, no. 11, 2022. https://doi.org/10.3390/genes13111929

Rosandić, Marija, Ines Vlahović, Ivan Pilaš, Matko Glunčić and Vladimir Paar. "An Explanation of Exceptions from Chargaff’s Second Parity Rule/Strand Symmetry of DNA Molecules." Genes 13, no. 11 (2022). https://doi.org/10.3390/genes13111929

Rosandić, M., et al. (2022) 'An Explanation of Exceptions from Chargaff’s Second Parity Rule/Strand Symmetry of DNA Molecules', Genes, 13(11). doi: 10.3390/genes13111929

Rosandić M, Vlahović I, Pilaš I, Glunčić M, Paar V. An Explanation of Exceptions from Chargaff’s Second Parity Rule/Strand Symmetry of DNA Molecules. Genes [Internet]. 2022 October 23 [cited 2024 December 24];13(11). doi: 10.3390/genes13111929

M. Rosandić, I. Vlahović, I. Pilaš, M. Glunčić and V. Paar, "An Explanation of Exceptions from Chargaff’s Second Parity Rule/Strand Symmetry of DNA Molecules", Genes, vol. 13, no. 11, October 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:217:175472. [Accessed: 24 December 2024]

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Metadata
Title (english)An Explanation of Exceptions from Chargaff’s Second Parity Rule/Strand Symmetry of DNA Molecules
AuthorMarija Rosandić
AuthorInes Vlahović
AuthorIvan Pilaš
AuthorMatko Glunčić
AuthorVladimir Paar
Author's institutionUniversity of Zagreb
Faculty of Science
(Department of Physics)
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Physics
Abstract (english)
In this article, we show that mono/oligonucleotide quadruplets, as basic structures of DNA, along with our classification of trinucleotides, disclose an organization of genomes based on purine–pyrimidine symmetry. Moreover, the structure and stability of DNA are influenced by the Watson–Crick pairing and the natural law of DNA creation and conservation, according to which the same mono- or oligonucleotide insertion must be inserted simultaneously into both strands of DNA. Taken together, they lead to quadruplets with central mirror symmetry and bidirectional DNA strand orientation and are incorporated into Chargaff’s second parity rule (CSPR). Performing our quadruplet frequency analysis of all human chromosomes and of Neuroblastoma BreakPoint Family (NBPF) genes, which code Olduvai protein domains in the human genome, we show that the coding part of DNA violates CSPR. This may shed new light and give rise to a novel hypothesis on DNA creation and its evolution. In this framework, the logarithmic relationship between oligonucleotide order and minimal DNA sequence length, to establish the validity of CSPR, automatically follows from the quadruplet structure of the genomic sequence. The problem of the violation of CSPR in rare symbionts is discussed.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleGenes
Numberingvol. 13, no. 11, 1929
e-ISSN2073-4425
DOIhttps://doi.org/10.3390/genes13111929
URN:NBNurn:nbn:hr:217:175472
Publication2022-10-23
ProjectNumber: IP-2019-04-2757
Title (croatian): Varijante u repetitivnim strukturama višeg reda u centromernim i NBPF dijelovima genoma čovjeka i viših primata
Title (english): Variants in higher order repeat structures in centromeric and NBPF regions of human and higher primates genomes
Acronym: HORVAR
Leader: Matko Glunčić
Jurisdiction: Croatia
Funding stream: Research Projects
Document URLhttps://www.mdpi.com/2073-4425/13/11/1929
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Public note© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Received: 18 September 2022. Accepted: 17 October 2022. Published: 23 October 2022.
Created on2024-08-23 09:39:05