Mechanobiology of the Mitotic Spindle

Scientific paper - Original scientific paper

• Author: Nenad Pavin
• Author: Iva Marija Tolić
• Author's institution: University of Zagreb; Faculty of Science; (Department of Physics)
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Physics

Abstract (english)

The mitotic spindle is a microtubule-based assembly that separates the chromosomes during cell division. As the spindle is basically a mechanical micro machine, the understanding of its functioning is constantly motivating the development of experimental approaches based on mechanical perturbations, which are complementary to and work together with the classical genetics and biochemistry methods. Recent data emerging from these approaches in combination with theoretical modeling led to novel ideas and significant revisions of the basic concepts in the field. In this Perspective, we discuss the advances in the understanding of spindle mechanics, focusing on microtubule forces that control chromosome movements.

• Keywords (english): mitotic spindle; microtubules; kinetochores; kinetochore fibers; bridging fibers; kinesins; forces; laser ablation; microneedle; theory; modeling
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review - international
• Publication version: Published version
• Journal title: Developmental Cell
• Numbering: vol. 56, no. 2, pp. 192-201
• p-ISSN: 1534-5807
• DOI: https://doi.org/10.1016/j.devcel.2020.11.003
• URN:NBN: urn:nbn:hr:217:275581
• Publication: 2021
• Project: Number: IP-2019-04-5967; Title (croatian): Ravnoteža sila i momenta sila u diobenom vretenu; Title (english): Balance of forces and torques in the mitotic spindle; Acronym: SpindleForceBalance; Leader: Nenad Pavin; Jurisdiction: Croatia; Funding stream: Research Projects
• Project: Number: PZS-2019-02-7653; Title (croatian): Mehanizmi nastajanja snopova mikrotubula potrebni za sazrijevanje diobenog vretena; Title (english): Mechanisms of microtubule bundle formation required for spindle maturation; Acronym: SpindleForm; Leader: Iva Marija Tolić; Jurisdiction: Croatia; Funding stream: Programme Research Cooperability
• Project: Number: KK.01.1.1.01.0004; Title (croatian): Provedba vrhunskih istraživanja u sklopu Znanstvenog centra izvrsnosti za kvantne i kompleksne sustave te reprezentacije Liejevih algebri; Title (english): Implementation of top research within the Scientific Center of Excellence for Quantum and Complex Systems, and Representations of Lie Algebras; Acronym: QuantiXLie; Leader: Hrvoje Buljan; Jurisdiction: eu; Funding stream: European Regional Development Fund
• Document URL: https://linkinghub.elsevier.com/retrieve/pii/S1534580720308789
• Type of resource: Text
• Access conditions: Open access
• Public note: © 2020 Elsevier Inc. Available online 24 November 2020, Version of Record 25 January 2021. Open access content, the Creative Commons licensing terms apply.
• Created on: 2024-09-15 16:01:50