Epigenetika tumora

undergraduate thesis

• Title (english): Epigenetics of cancer
• Author: Marta Jančić
• Mentor: Mirjana Pavlica (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2024-09-19, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Unatoč svakodnevnom napretku znanosti i medicine, dijagnosticiranje i liječenje najučestalijih bolesti poput tumora još uvijek predstavlja izazov. Iako su tumori tradicionalno smatrani genetičkom bolešću, novija istraživanja ukazuju na ključnu ulogu epigenetike u njihovom nastanku i progresiji. Ključno istraživačko pitanje ovog rada je: Kako epigenetske promjene utječu na nastanak i razvoj tumora? Epigenetske promjene, uključujući metilaciju DNA, regulaciju miRNA te modifikacije histona i kromatina, utječu na ekspresiju gena i druge stanične procese. Tumori mogu nastati pod utjecajem genetičkih ili epigenetskih čimbenika, ili njihovom kombinacijom. Razvoj i progresija mnogih malignih bolesti, poput akutne mijeloične leukemije, usko su povezani s epigenetskim modifikacijama, a nove terapijske metode fokusiraju se na reverzibilnost tih promjena ili njihovu inhibiciju. Osim što su ključne za razvoj budućih strategija liječenja, epigenetske modifikacije također služe kao potencijalni biomarkeri za rano otkrivanje i praćenje napredovanja bolesti.

Abstract (english)

Despite daily advancements in science and medicine, diagnosing and treating prevalent diseases such as tumors still present significant challenges. Although tumors have been traditionally considered as genetic diseases, recent research highlights the crucial role of epigenetics in their onset and progression. The key research question of this study is: How do epigenetic changes influence the development and progression of tumors? Epigenetic modifications, including DNA methylation, miRNA regulation, histone and chromatin modifications, affect gene expression and subsequent cellular processes. Tumors can arise due to genetic or epigenetic factors, or a combination of both. The development and progression of many malignancies, such as acute myeloid leukemia, are closely linked to epigenetic modifications, with emerging therapeutic approaches focusing on reversing or inhibiting these changes. In addition to being essential for future treatment strategies, the presence of epigenetic modifications in tumors may serve as potential biomarkers for early detection and monitoring disease progression.

• Keywords: epigenetika; mehanizmi; tumor; akutna mijeloična leukemija; terapija
• Keywords (english): epigenetics; mechanisms; tumour; acute myeloid leukemia; therapy
• Language: croatian
• URN:NBN: urn:nbn:hr:217:423626
• Study programme: Title: Molecular biology-University undergraduate programme; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-10-03 09:25:08