Neciljani metabolomski pristup u funkciji otkrivanja terapijskog učinka duloksetina i fototerapije kod pacijenata s dijagnozom velikog depresivnog poremećaja

master's thesis

• Title (english): An untargeted metabolomic approach for the purpose of detecting the effect od duloxetine and bright light therapy in patients diagnosed with major depressive disorder
• Author: Lavinia Latin
• Mentor: Matea Nikolac Perković (mentor)
• Committee member: Morana Dulić (predsjednik povjerenstva)
• Committee member: Ivan Nemet (član povjerenstva)
• Committee member: Željka Soldin (član povjerenstva)
• Committee member: Marko Močibob (član povjerenstva)
• Granter: University of Zagreb; Faculty of Science; (Department of Chemistry); Zagreb
• Defense date and country: 2025-02-25, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry

Abstract

Veliki depresivni poremećaj ozbiljan je mentalni poremećaj koji značajno narušava kvalitetu života, radnu sposobnost te interpersonalne odnose. Očituje se dugotrajnim lošim raspoloženjem, gubitkom interesa, smanjenjem energije te kognitivnim i somatskim simptomima. Farmakološka terapija najčešće uključuje antidepresive iz skupine selektivnih inhibitora ponovne pohrane serotonina i noradrenalina, poput duloksetina, dok se u nekim slučajevima primjenjuju i nefarmakološke metode poput... More fototerapije. Metabolomika, interdisciplinarna znanost koja se bavi analizom metabolita u biološkim uzorcima, pruža uvid u biokemijske promjene ovog poremećaja. Neciljano metabolomsko profiliranje plazme pacijenata omogućuje identifikaciju biomarkera povezanih s patofiziologijom poremećaja i odgovorom na terapiju. Tehnologije poput plinske kromatografije spregnute sa spektrometrijom mase ključne su za analizu metabolita, omogućujući detekciju i kvantifikaciju promjena u metabolizmu lipida, aminokiselina i energetskih puteva. Univarijatna i multivarijatna statistička obrada rezultirala je sa značajno promijenjenim zastupljenostima metabolita unutar ispitivanih skupina koji služe kao biomarkeri za prilagodbu i odabir strategije liječenja velikog depresivnog poremećaja. Less

Abstract (english)

Major depressive disorder is a severe mental disorder that significantly impairs quality of life, work capacity, and relationships. It manifests as prolonged low mood, loss of interest, reduced energy, and cognitive and somatic symptoms. Treatment often includes antidepressants inhibiting serotonin and norepinephrine reuptake, such as duloxetine, while non- pharmacological methods like phototherapy are sometimes used. Metabolomics, an interdisciplinary science analyzing... More metabolites in biological samples, provides insight into the biochemical changes of this disorder. Untargeted metabolomic profiling of patient plasma enables the identification of biomarkers associated with the disorder's pathophysiology and response to therapy. Technologies such as gas chromatography-mass spectrometry are crucial for metabolite analysis, allowing the detection and quantification of changes in lipid, amino acid, and energy metabolism. Univariate and multivariate statistical analysis revealed significantly altered metabolite levels within the studied groups, serving as biomarkers for optimizing and selecting treatment strategies for major depressive disorder. Less

• Keywords: biomarkeri; duloksetin; fototerapija; metabolomika; veliki depresivni poremećaj
• Keywords (english): biomarkers; duloxetine; major depressive disorder; metabolomics; phototherapy
• Language: croatian
• URN:NBN: urn:nbn:hr:217:018504
• Project: Number: IPS-2022-02-2497; Title: Cirkulirajuće ekstracelularne vezikule kao prediktori antidepresivnog odgovora: Praćenje mehanizma djelovanja novih terapijskih pristupa u depresiji; Title: Circulating Extracellular Vesicles as Predictors of Antidepressant Response: Monitoring the Mechanism of Novel Therapeutic Approaches in Depression; Acronym: EVroPAR; Leader: Matea Nikolac Perković; Jurisdiction: Croatia; Funder: Hrvatska zaklada za znanost; Funding stream: Slovenian-Croatian Bilateral Projects
• Study programme: Title: Graduate university studies in chemistry; specializations in: Graduate university studies in chemistry; Course: Graduate university studies in chemistry; Study programme type: university; Study level: graduate; Academic / professional title: sveučilišni/a magistar/magistra kemije (sveučilišni/a magistar/magistra kemije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2025-03-24 14:16:47