Novi pristupi u dokidanju otpornosti stanica tumora na kemoterapiju

undergraduate thesis

• Title (english): New approches in overcoming cancer cell resistance to chemotherapy
• Author: Antonija Sudarević
• Mentor: Nada Oršolić (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2017, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Različite vrste tumora danas su jedan od vodećih uzroka smrtnosti u svijetu. Tumorske stanice imaju sposobnost nekontroliranog, autonomnog i neograničenog rasta te su kao posljedica genetičke nestabilnosti razvile broje mehanizme otpornosti na tradicionalne oblike liječenja. Otpornost stanica tumora na kemoterapiju glavni je problem liječenja protutumorskim lijekovima, stoga se u današnje vrijeme sve više istražuju nove metode kojima bi se to spriječilo, a samim time i povećala uspješnost izlječenja. U ovom radu izložen je kratki pregled nekih od novih pristupa, u prevladavanju otpornosti tumorskih stanica- korištenje nanočestica, imunoterapije i biljnih polifenola. Takvi novi pristupi djeluju na mehanizme otpornosti kao što su povećano izbacivanja lijeka iz stanice, smanjenje unosa lijeka u stanicu, smanjenje vezanja protutumorskih lijekova na ciljne molekule unutar stanice te aktivacija signalnih puteva koji inhibiraju apoptozu. Metode navedene u ovom radu zahtijevaju dodatna ispitivanja i usavršavanja kako bi se u skorijoj budućnosti mogle efikasno koristiti za liječenje različitih oblika tumora.

Abstract (english)

One of the leading causes of mortality in the world nowadays are different types of tumors. Tumor cells have the ability of uncontrolled, autonomous and unrestricted growth and as a result of their genetic instability, they have developed numerous mechanisms of resistance to traditional forms of treatment. The resistance of tumor cells to chemotherapy is a major problem in treatment with anti-inflammatory drugs, so new methods are being explored to prevent this and thus increase the success of the treatment. In this paper , a short review of some of the new approaches in overcoming the resistance of tumor cells such as using nanoparticles, immunotherapy and plant polyphenols, has been presented. These new approaches act on the resistance mechanisms such as increased activity of drug efflux , reduced drug intake, reduced binding of anti-inflammatory drugs to the target molecules within the cell, and activation of signal pathways that inhibit apoptosis. The methods outlined in this paper require further examinations and enhancements to be able to efficiently use in the near future to treat various types of tumors.

• Keywords: tumor; liječenje tumora
• Keywords (english): tumor; tumor treatment
• Language: croatian
• URN:NBN: urn:nbn:hr:217:870147
• Study programme: Title: Molecular Biology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2017-10-10 07:18:57