Bioinformatičke metode sastavljanja genoma de novo

undergraduate thesis

• Title (english): Bioinformatics methods of de novo genome assembly
• Author: Dunja Glavaš
• Mentor: Kristian Vlahoviček (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2014, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Tehnologije sljedeće generacije omogućile su brzo i jeftino sekvenciranje genoma. Programi za sastavljanje obrađuju izlazne podatke takvih eksperimenata. Pri sastavljanju cjelovite sekvence iz fragmentiranih sljedova oslanjaju se na neki od tri pristupa: pohlepni algoritam, metodu OLC ili de Bruijnov graf. Rad ukratko opisuje svaki od tri algoritma te proces sklapanja okvira, koji je sljedeći korak kod slaganja genoma.

Abstract (english)

Next-generation technologies have made genome sequencing cheap and fast. Genome assemblers are programs which process output data from such experiments. When computing a complete genomic sequence from many smaller fragments, they take one of the three main approaches: greedy, OLC or de Bruijn graph. This paper describes the main points in each of the three algorithms, as well as the scaffolding process, which is the next step in genome assembly.

• Keywords: genom
• Keywords (english): genome
• Language: croatian
• URN:NBN: urn:nbn:hr:217:611407
• Study programme: Title: Molecular Biology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2017-12-06 13:11:08